BlueFlowCell · Synthesis of methylene blue and some new thioether derivatives with an enhanced electrochemical microflow cell
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2020-09-01 → 2022-08-31
- EU contribution
- €184,708
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
Synthesis of methylene blue and some new thioether derivatives with an enhanced electrochemical microflow cell
Methylene blue is the first fully synthetic drug used in medicine, the most effective and safe medicines needed in a health system. These compounds are synthesized commercially by chemical methods that suffer from ignificant limitations, such as expensive and toxic reagents, solvents, tedious work-up, safety problems. Organic electrosynthesis is recognized as a typical environmentally friendly process with features that many of which cannot be achieved by other methods. Within this field, the use of microreactors in continuous flow is also concurrent with electrochemistry because of its convenient advantages over batch, such as no supporting electrolyte; high electrode surface-to-reactor volume ratio, and, short residence time. in this project, we will first design and manufacture an electrochemical microflow cell prototype with the help of photolithography technique to fabricate microchannels. Its efficiency will be tested with the known reaction and the effect of height and geometry of microchannels on electrosynthesis efficiency and mass transfer will then be investigated. After the optimal parameters are determined, Methylene blue will finally be synthesized with the improved flow reactor to demonstrate the efficiency. As well as, during the whole of the project the ER will gain maximum knowledge in microfluidic integrated devices and benefit from entrepreneurship skills.
Data: CORDIS, © European Union
Project objective
Methylene blue is the first fully synthetic drug used in medicine, the most effective and safe medicines needed in a health system. In addition, thioethers derivatives are important materials that are used in organic, bioorganic and medicinal chemistry and are also known to exhibit different biological activities such as antioxidant and antibacterial. These compounds are synthesized commercially by chemical methods that suffer from significant limitations, such as expensive and toxic reagents, solvents, tedious work-up, safety problems. Organic electrosynthesis is recognized as a typical environmentally friendly process with features that many of which cannot be achieved by other methods. Most electroorganic processes are performed under reagentless and mild conditions in one step using efficient and ecofriendly methods and are in agreement with all the principles of green chemistry. Within this field, the use of microreactors in continuous flow is also concurrent with electrochemistry because of its convenient advantages over batch, such as no supporting electrolyte at all, due to the small distance between electrodes; high electrode surface-to-reactor volume ratio, short residence time and etc. This project aims to fabricate an electrochemical flow microreactor by the novel method of photolithography to decrease the interelectrode gap below 100µm. Thus, the resulting device should be suited to the electrosynthesis of a wide range of reactions without a supporting electrolyte solution. Through the present project, we also aim electrochemical synthesis of methylene blue and some new thioethers derivatives for the first time with a facile one-pot and supporting electrolyte-free method. Overall, this method has shown to be a promising tool for electrosynthesis and improving the outcome of standard batch cells. As well as, during the whole of the project the ER will gain maximum knowledge in microfluidic integrated devices and benefit from entrepreneurship skills.
Original text from CORDIS.
Participants
- BLACK HOLE LAB · ParisCoordinatorFrance
Links
Data: CORDIS, © European Union