BrainwideNeuroCaSens · Calcium-sensitive functional Magnetic Resonance Imaging as a breakthrough technique to follow brain-wide intracellular calcium dynamics defining multi-scale neuronal activity

Calcium-sensitive functional Magnetic Resonance Imaging as a breakthrough technique to follow brain-wide intracellular calcium dynamics defining multi-scale neuronal activity

In the vast labyrinth of scientific inquiry, amidst the intricate networks of neurons firing within the human brain, lies a fundamental challenge: the absence of a comprehensive method to measure neural activity across the entire brain. This elusive measurement, long sought after by neuroscientists, is critical for unraveling the mysteries of brain function and dysfunction. At the heart of this quest is the quest for a brain-wide indicator of neural activity—a measure that transcends the limitations of current techniques. For years, researchers have relied on the release of calcium ions within neurons as a proxy for neural activity. This method, utilizing fluorescent calcium indicators, has stood as the pinnacle of system neuroscience applications. However, despite its widespread use, it falls short in providing a holistic view of brain-wide signaling. Why does this matter beyond the confines of the laboratory? Imagine a world where we can peer into the intricate dance of neural activity across the entire brain, from its most basic functions to the complexities of cognitive processes. Such insight would not only deepen our understanding of how the brain operates under various physiological conditions but also offer invaluable insights into neurological disorders and conditions where neural networks falter. Enter the BrainwideNeuroCaSens project—an ambitious endeavor with the singular objective of revolutionizing our ability to measure neural activity. At its core, the project seeks to pioneer a groundbreaking technique known as calcium-dependent functional Magnetic Resonance Imaging (Ca-fMRI). This novel approach holds the promise of providing minimally invasive, yet direct, readouts of neural activity. Through Ca-fMRI, researchers aim to unlock the door to brain-wide intracellular calcium dynamics—a feat previously thought unattainable. By harnessing the power of functional MRI, which offers three-dimensional insights over large areas of the mammalian brain, Ca-fMRI promises to transcend the limitations of existing methods. It is poised to usher in a new era of neuroscience, one where the intricacies of global brain activity can be explored with unprecedented detail and translational relevance. In essence, the objectives of the BrainwideNeuroCaSens project are twofold: to develop Ca-fMRI as a next-generation imaging technology and to utilize this tool to investigate the nuances of global brain activity. By doing so, the project aims to bridge the gap between basic research and clinical applications, paving the way for transformative discoveries with far-reaching implications for society.

Data: CORDIS, © European Union