SERENA · Development of an electrochemical multiSEnsor platform for the simultaneous detection of emerging bREast caNcer biomArkers in a blood droplet
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2022-02-01 → 2024-01-31
- EU contribution
- €160,932
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
Development of an electrochemical multiSEnsor platform for the simultaneous detection of emerging bREast caNcer biomArkers in a blood droplet
Problem/Issue Addressed: The project aims to address the unmet needs in the field of cancer diagnosis. The focus is on breast cancer, which remains one of the leading causes of cancer-related mortality in women worldwide. Despite significant advances in treatment, early diagnosis, assessment of prognosis and prediction of treatment response remain crucial. Importance for Society: Early detection of cancer significantly improves patient outcomes. Liquid biopsy, a less invasive alternative to tissue biopsy, is a promising approach for early diagnosis, prognosis assessment and therapy monitoring. The development of reliable, rapid, and cost-effective diagnostic tools is crucial for improving cancer management and reducing mortality rates. Overall Objectives: The overall objective of the project is to develop a novel electrochemical nanostructured multisensor platform for the rapid, cost-effective and reliable detection of novel breast cancer biomarkers, including non-coding RNAs (ncRNAs) and autoantibodies (AAbs), in whole blood. This platform aims to facilitate early cancer diagnosis, prognosis assessment and patient follow-up. The fellowship provided me with a broad range of expertise, that significantly improved my career prospects. With my improved scientific skills and proposal writing ability, I aim to secure higher academic positions and apply for grants such as the ERC Starting Grant to eventually become independent as a Principal Investigator.
Data: CORDIS, © European Union
Project objective
This proposal aims to address the unmet needs, opportunities, and challenges in the field of liquid biopsy and PoC devices for the detection of emerging cancer biomarkers in blood. Circulating microRNAs and long non-coding RNAs as well as autoantibodies are promising cancer biomarkers for liquid biopsy. My goal is to develop a rapid, portable, easy-use, and reliable electrochemical nanostructured multisensor platform for their simultaneous detection in whole blood for early breast cancer diagnosis, prognosis and patient follow-up. I will merge the advantages of nucleic acid analogues with those of graphene-nanoparticle hybrid composites to develop a platform based on the use of inexpensive screen printed electrodes, produced by cutting-edge green technologies.An interdisciplinary approach will drive me towards the development and delivery of this novel diagnostic device with tremendous potential in nanomedicine. This fellowship aims to build on my recognised background in DNA nanotechnology and achieve new complementary expertise in electrochemistry, cutting-edge nanotechnology and nanoscience-based biosensors, through knowledge transfer and related training activities under the supervision of Prof. Merkoçi, a world-renowned expert in these fields. Meanwhile, the host institution (ICN2) will benefit from my skills in DNA nanotechnology for bioanalytical applications. Moreover, this fellowship will allow me to refine and acquire complementary transferable skills, including proposal writing, patents and IPR, project management, and leadership skills. I intend also exploit the opportunities to develop professionally by supporting the ICN2 Communication Department and by getting involved in the ICN2’s gender actions.The original scientific output and added-value career development benefits of this fellowship would greatly support me in gaining the necessary skills and credentials to become an independent and productive European PI.
Original text from CORDIS.
Participants
- FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA · BELLATERRA (BARCELONA)CoordinatorSpain
Links
Data: CORDIS, © European Union