OCTOPUS · Oncological Concurrent Tomographic Optoacoustics, Pet and UltraSonography.
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2022-06-01 → 2024-05-31
- EU contribution
- €160,932
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
OCTOPUS: Oncological Concurrent Tomographic Optoacoustics, Pet and UltraSonography.
The OCTOPUS (Oncological Concurrent Tomographic Optoacoustics, Pet and UltraSonography) project aimed to create a new multimodal imaging tool to correlate molecular, vascular and tissue oxygenation information, three of the main hallmarks of cancer, in a longitudinal, simultaneous, quantitative, fully co-registered and in vivo manner. Because cancer is a complex disease involving multiple hallmarks, many of the recently developed therapies, described as precision medicine, target these hallmarks. Imaging techniques are crucial tools for analysing the stage, characteristics, and relationship between several of these hallmarks. However, until recently these analyses were performed from separate imaging modalities, taken at different physiological states, making multiparametric correlation difficult. The OCTOPUS project will build the first in vivo and multimodal preclinical tool that investigates simultaneously the interactions between tissue oxygenation by Multispectral Optoacoustic Imaging, vascularization by Ultrafast Ultrasound Imaging, and Metabolism, employing super-resolved PET imaging. OCTOPUS will also provide a machine learning-based platform for advanced multi-parametric analysis of all image-derived tissue features that can be extracted with this equipment, in order to facilitate the interpretation of underlying tumoral mechanisms and ultimately guide the design or tailoring of targeted therapies.
Data: CORDIS, © European Union
Project objective
Cancer is the second leading cause of death globally. Noninvasive imaging of tumor hallmarks helps to combat cancer more efficiently. However, cancer is a complex disease and modern imaging of cancer should evolve to help exploring the interaction between different cancer hallmarks and to predict the evolution of some of them in relation to others. Besides, these new techniques should provide answers to the present unmet need for determining, precisely, how, which and when targeted therapeutic agents can be used for optimized efficacy. In this project we will build a new hybrid cancer imaging device: OCTOPUS (Oncological Concurrent Tomographic Optoacoustics, PET and UltraSonography), that will pioneer the intersection of molecular, vascular and tissue oxygenation information, three major hallmarks of cancer. OCTOPUS is a timely action to study tumor dynamics with a hybrid hallmark perspective in a longitudinal, simultaneous, quantitative, fully co-registered and in vivo manner. To reach this goal, I will develop cutting-edges technologies regarding multispectral tomographic optoacoustic using an arrangement of 3D ultrasound arrays, combined with actual 3D sequences of Ultrafast Ultrasound and a custom-made PET system for data acquisition and reconstruction. A deep learning framework will be created for advanced multiparametric analysis of OCTOPUS derived data to facilitate the interpretation of intra-tumoral processes in order to improve high-precision image-guided treatment and ultimately to guide in the design of targeted therapies.
Original text from CORDIS.
Participants
- UNIVERSIDAD COMPLUTENSE DE MADRID · MadridCoordinatorSpain
Links
Data: CORDIS, © European Union