HiFi Brilliancy · HIgh-speed FIbre-based BRILLouIn ANalyzer for endosCopY
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2022-06-01 → 2024-05-31
- EU contribution
- €202,681
- Participants
- 1
- Scheme
- MSCA-IF
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Results in brief
HIgh-speed FIbre-based BRILLouIn ANalyzer for endosCopY
Non-invasive and invasive endoscopically assessable cancers are among the ten deadliest cancers in the world, with a yearly mortality rate of over 1.5M. Timely diagnosis and treatment make it possible to reverse their development if detected in the early preclinical stages. One of the ways to improve the quality of modern clinical practice is the use of optomechanical diagnostic methods. The advantages of such methods are associated with their non-invasiveness, good resolving power, low procedure cost, and high productivity while controlling tumour progression, penetration of therapeutic agents, and drug resistance. Although the role and importance of mechanical properties of cells and tissues in cancer diagnosis and treatment are widely acknowledged, standard techniques currently used to assess them exhibit intrinsic limitations. In this project, we have elevated emerging fibre-based laser and sensor technologies and implemented them in a single Brillouin Imaging system to introduce a new engineering approach capable of controlling tissue elasticity both invasively or noninvasively through the measurement of the Brillouin gain spectrum in the tested biomaterial. The specific feature of the developed system is its simple all-fibre spliced format that does not need the use of expensive spectrometry tools. Supplied by only one single-mode optical fibre input/output interface compatible with standard one fibre endoscopic devices and demonstrated for operation at one particular wavelength, the general system design is replicable for any arbitrary wavelength, and hence, the optimal wavelength in regard of the Brillouin shift and Brillouin gain for a specific probe can be used. In testing experiments, reflecting the spirit of preclinical research, the system was able to detect alterations in sound velocity within the tested substrate with an accuracy better than 1% and a dynamic range of more than 30%. The Fellowship has successfully reached its ultimate goal of training a talented researcher, Dr Andrei Fotiadi, through a challenging research project on developing a novel approach to micromechanical imaging in biomaterials for in vivo real-time endoscopy. Gradually expanding his collaboration network in the EU and internationally, the Fellow has reinforced his professional maturity. According to the project results, 21 works were published, including 12 peer-reviewed articles and 9 conference proceedings. The results of the work were reported at 8 conferences. The Fellow’s h-index is increased by ~13.
Data: CORDIS, © European Union
Project objective
The ultimate goal of this Fellowship, entitled “HIgh-speed FIbre-based BRILLouIn ANalyzer for endosCopY” (HIFI BRILLIANCY) is to enhance the creative and innovative potential of an experienced researcher, helping him to diversify his individual competence through a research project focused on the development of novel tools for optomechanical imagine of biomaterials towards in vivo real-time endoscopy. This will be achieved putting forward the latest methods of stimulated Brillouin scattering enabling recording Brillouin Gain Spectra in biomaterials. The Fellow – Dr Andrei Fotiadi – will be trained in biophotonics, a fast-growing field of science, and medical application. The HiFi Brilliancy outputs will be relevant to the EU Information Science and Engineering sector by offering new cost-efficient technologies for real-time in vivo Brillouin Imaging. Given the huge and fast-growing market of medical diagnostic equipment, the project results have a good opportunity for successful commercialisation. The Fellow will use his present connections to optical equipment manufacturers in EU to develop commercialisation opportunities, and new connections will be established through this project. The project brings together an experienced research Fellow with a strong scientific and engineering background in Brillouin photonics and an internationally growing group of researchers at Opto-Electronics and Measurement Techniques (OPEM) unit (University of Oulu, Finland) with expertise in the area of developing laser-based photonic devices for biomedical imaging. The Fellow will be further supported by medical and industrial expert co-hosts who will help train the Fellow in key skills and support the translational research process. The translational part of the project will primarily be aimed at adapting results of scientific studies to actual conditions of clinical practice. It will permeate the whole project and will be a complex of scientific research and training of the Fellow.
Original text from CORDIS.
Participants
- OULUN YLIOPISTO · OuluCoordinatorFinland
Links
Data: CORDIS, © European Union