neurOmics · Novel Methods to Identify Endocrine Disruption Induced Neurotoxicity
Horizon Europe — Marie Skłodowska-Curie Actions
- Duration
- 2023-05-01 → 2026-08-31
- EU contribution
- €220,846
- Participants
- 2
- Scheme
- HORIZON-TMA-MSCA-PF-GF
Lines connect the coordinator with its partners.
Results in brief
Novel Methods to Identify Endocrine Disruption Induced Neurotoxicity
By using cutting-edge methods within developmental neurotoxicity and endocrine disruption, neurOmics will use exploratory omics in a powerful alterative model system to form novel hypotheses on how endocrine disrupting chemicals affect the brain. The project will utilize a representative of true frogs, the cosmopolitan tadpole model American bullfrog (Rana [Lithobates] catesbeiana), to understand the causes of developmental neurotoxicity (DNT) and exploit this gained knowledge to establish adverse outcome pathways (AOPs) applicable for risk assessment of chemicals — a European Commission priority focus area and supporting the Green Deal ‘a toxic-free environment. Currently, the incidence of neurodevelopmental disorders such as attention deficit hyperactivity disorders and autism spectrum disorders are increasing among children; a trend that has been linked to man-made chemicals suspected of causing developmental neurotoxicity. Thyroid hormone signaling is well-known for playing an essential role in brain development in all vertebrates. Hence, thyroid hormone system disrupting chemicals are likely candidates for causing developmental toxicity. Despite this, the current guidelines are insufficient to properly identify chemicals that are toxic for the developing brain and scientists across the world have recently called for better testing methods. The proposed project aims to develop novel testing strategies that will have a far-reaching impact and contribute to breaking down the wall between human and environmental toxicology. This will enable for a better and more feasible identification and safety assessment of hazardous chemicals, ultimately reducing the neurodevelopmental disorders observed among children today.
Data: CORDIS, © European Union
Project objective
Currently, the incidence of neurodevelopmental disorders such as attention deficit hyperactivity disorders and autism spectrum disorders are increasing among children; a trend that has been linked to man-made chemicals suspected of causing developmental neurotoxicity (DNT). Despite this, the current guidelines are insufficient to properly identify chemicals that are toxic for the developing brain and scientists across the world have recently called for better DNT testing methods. neurOmics will find new approaches to evaluate endocrine disruption induced DNT. Using cutting-edge molecular methods neurOmics will apply exploratory omics in a powerful alternative model system to form novel hypotheses on how endocrine disrupting chemicals affect the brain. We propose that lipids and myelination represent promising key events for endocrine disruptor-induced DNT and by using technologies such as high-resolution mass spectrometry and Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging, we will move the field from a point where hazard characterization relies on fluctuating hormone measurements to more reliable, feasible and quantifiable molecular key events. The project will utilize a representative of true frogs, the cosmopolitan tadpole model American bullfrog (Rana [Lithobates] catesbeiana), to understand the causes of DNT and exploit this gained knowledge to establish adverse outcome pathways (AOPs) applicable for risk assessment of chemicals — a European Commission priority focus area and supporting the Green Deal. Neurodevelopment is highly conserved across animal species so the novel testing strategies will contribute to breaking down the wall between human and environmental toxicology. This will enable for a better and more feasible identification and safety assessment of hazardous chemicals, improve ecosystem health and ultimately reduce the neurodevelopmental disorders observed among children today
Original text from CORDIS.
Participants
Links
- View on CORDIS
- DOI: 10.3030/101068090
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e507852bdc&appId=PPGMS
Data: CORDIS, © European Union