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HEDoctoral network2023–2026

TheraTools · Innovative tools to treat and model complex cancer environments

Horizon Europe — Marie Skłodowska-Curie Actions

Duration
2023-01-01 → 2026-12-31
EU contribution
€2,291,119
Participants
13
Scheme
HORIZON-TMA-MSCA-DN-JD

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Results in brief

Innovative tools to treat and model complex cancer environments

TheraTools has arisen as a multidisciplinary research and training network that encompasses a full academical and technological view of the development of scientific tools for the comprehensive research of malignant tumors localized beyond a biological barrier, as in brain tumors. This challenging objective needs of the concerted effort of both academic and industrial organizations. As such, TheraTools is formed by a consortium composed by (a) four academic beneficiaries (POLYMAT-University of the Basque Country, Spain; University of Aveiro, Portugal; Italian Institute of Technology, linked to Sant´Anna School of Advanced Studies, Italy, and Technion – Israel Institute of Technology, Israel). All the partners will be involved in both research and training activities framed within this network. Specifically, TheraTools doctoral network has been carefully tailored to set up a supportive environment that instructs future leaders in the area of the development and validation of therapeutics, covering research and training areas that include biochemistry, polymer chemistry, microfluidics, 3D printing, biology, drug delivery, fabrication of cancer models, cell biology, and therapeutics. The participation of the consortium of several industrial partners makes TheraTools highly intersectorial and provides the opportunity to young researchers to follow the industrial path of the products/services that they develop in the laboratory. TheraTools consortium aims to develop novel strategies to ensure an effective transport of biomacromolecular therapeutics across biological barriers, while protecting them from protease degradation/denaturation and allowing their sustained release at the target site to avoid off-target side-effects. In parallel, TheraTools aims at assembling biomimetic real-scale models including vascularised tumors (and not individualized cancer cells) and sensors in close proximity of the cells to facilitate temporal and spatial resolution of cell-cell and cell-therapeutic interactions, which could pave the way towards monitoring the dynamic tumor responses with much higher accessibility compared to current in vitro and in vivo models.

Data: CORDIS, © European Union

Project objective

TheraTools has arisen as a multidisciplinary research and training network that encompasses a full academical and technological view of the development of scientific tools for the comprehensive research of malignant tumors localized beyond a biological barrier, as in brain tumors. This challenging objective needs of the concerted effort of both academic and industrial organizations. As such, TheraTools is formed by a consortium composed by (a) four academic beneficiaries(POLYMAT-University of the Basque Country, Spain; University of Aveiro, Portugal; Italian Institute of Technology, linked to Sant´Anna School of Advanced Studies, Italy, and Technion – Israel Institute of Technology, Israel); and (b) 6 industrial partners: Polimerbio (Spain), BEONCHIP (Spain), Metatissue (Portugal), Vetex (Cyprus), I+Med (Spain), and Nanoscribe (Germany). All the partners will be involved in both research and training activities framed within this network.TheraTools consortium and working plan has been configured to stablish a supportive network within a EJD in the topic of the development of “Innovative tools to treat and model complex cancer environments”. This network considers the engagement of 9 early-stage researchers that will have the opportunity to be awarded with double doctorate degrees in two different countries. TheraTools network will offer to the ESRs high quality training opportunities across several disciplines to conceive a full view of the development of therapeutics, from the synthesis of the drugs to their validation in in-vitro models. In its endeavor to translate the experience of the participants into products for health benefit, TheraTools will transfer the knowledge and competences to young researchers, providing them with enhanced career perspectives in both the academic and non-academic sectors through international, interdisciplinary, and inter-sectorial mobility combined with an innovation-oriented mindset and an excellence level of training.

Original text from CORDIS.

Participants

  • UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA · LeioaCoordinatorSpain
  • BEONCHIP SL · ZaragozaSpain
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA · GenovaItaly
  • I+MED S COOP · VITORIA-GASTEIZSpain
  • IVTECH SRL · MassarosaItaly
  • METATISSUE - BIOSOLUTIONS, LDA · IlhavoPortugal
  • NANOSCRIBE GMBH · EGGENSTEIN-LEOPOLDSHAFENGermany
  • Polimerbio, S.L. · San SebastianCity levelSpain
  • SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA · PisaItaly
  • TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY · HaifaIsrael
  • TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD · HaifaIsrael
  • UNIVERSIDADE DE AVEIRO · AveiroPortugal
  • VET EX MACHINA LIMITED · NICOSIACyprus

Links

Data: CORDIS, © European Union