SUCCEED · Multi-modal characterization of the subcortical involvement in focal epilepsy
Horizon Europe — Marie Skłodowska-Curie Actions
- Duration
- 2023-01-01 → 2024-12-31
- EU contribution
- €211,755
- Participants
- 1
- Scheme
- HORIZON-TMA-MSCA-PF-EF
Lines connect the coordinator with its partners.
Results in brief
Multi-modal characterization of the subcortical involvement in focal epilepsy
Focal epilepsy is a chronic brain disorder that causes repeated, spontaneous seizures that start in specific parts of the brain. These seizures often spread to other areas, affecting overall brain function and cognition. Although some evidence suggests that deeper brain regions play a role in the spread of these seizures, we do not fully understand how this happens. In this project (‘SUCCEED’), I will study focal epilepsy by using 7 Tesla MRI to get a detailed look at the deeper parts of the brain. By doing this, I hope to uncover important connections between these areas and epilepsy, which could explain the variety in symptoms and treatment success among patients. Specifically, I will: Objective 1: Use MRI scans to map the connections between deep brain regions in both epilepsy patients and healthy individuals. This will help us understand how these connections differ in patients. Objective 2: Measure various properties of these deep brain regions using MRI, to see what changes occur in the brains of epilepsy patients compared to healthy controls. Objective 3: Explore how these MRI findings relate to the patient’s symptoms and treatment outcomes. By doing this, we aim to identify specific patterns in the deep brain regions that could serve as biomarkers for epilepsy.
Data: CORDIS, © European Union
Project objective
Focal epilepsy is a chronic neurological disorder characterized by repeated spontaneous seizures that originate from one or several confined regions. After onset, these seizures often propagate towards networks of regions spread across the brain, negatively affecting whole-brain dynamics and cognitive functioning in these patients. Despite evidence advocating the involvement of subcortical areas in seizure organisation in some patients, the exact mechanisms are still poorly understood. Therefore, I anticipate that multimodal, high resolution characterization of the subcortex using 7 Tesla MRI data provides an important, missing link to enhance our understanding of changes within, and differences between focal epilepsy patients. I will explore this in three aims that focus on network integrity, tissue integrity and disease heterogeneity. Successful completion of the objectives is maximized by a two-way transfer of knowledge by combining my proficiency in quantitative brain mapping and computational neuroimaging with the host’s expertise related to brain network analyses in epilepsy. Together these techniques provide a platform for ‘SUbCortical Characterization to Enhance Epilepsy Differentiation’ (SUCCEED) and will advance the development of non-invasive subcortical biomarkers towards personalized diagnosis and treatment of focal epilepsy. Results will be communicated to the scientific and non-scientific public through scientific publications, conference presentations, via Twitter, workshops and open days. With the host lab situated at the forefront of epilepsy research, it will provide the ideal environment to improve my scientific network, and receive the relevant technical and personal training. Together with the innovative and interdisciplinary nature of the project, this will give me the unique opportunity to mature further towards an independent researcher both during and after the fellowship.
Original text from CORDIS.
Participants
- UNIVERSITE D'AIX MARSEILLE · MarseilleCoordinatorFrance
Links
- View on CORDIS
- DOI: 10.3030/101061988
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e50fa50ab4&appId=PPGMS
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5155ae45b&appId=PPGMS
Data: CORDIS, © European Union