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HEDoctoral network2022–2026

DYNAMO · DYnamic control in hybrid plasmonic NAnopores: road to next generation multiplexed single MOlecule detection

Horizon Europe — Marie Skłodowska-Curie Actions

Duration
2022-09-01 → 2026-08-31
EU contribution
€2,628,403
Participants
12
Scheme
HORIZON-TMA-MSCA-DN

Lines connect the coordinator with its partners.

Results in brief

DYnamic control in hybrid plasmonic NAnopores: road to next generation multiplexed single MOlecule detection

DYNAMO is designed as an innovative and pioneering training network, with the unique vision of developing the next-generation hybrid nanopore technology exploiting DNA nanostructures integrated with multifunctional solid-state platforms, by: • Bringing together a unique team of 6 world-leading academic groups, at the forefront of nanoscience and single molecule sensing and manipulation, and 1 high tech company, to translate the innovations into real-world applications; • Training 10 Junior Researchers (JR) on a unique mix of experimental and computational skills at the physics/chemistry/biotechnology interface; • Enabling technological advances through the combination of enhanced optical spectroscopies, (magneto)plasmonics and DNA nanotechnology. This will lead to the development of nanopore technologies with unprecedented functionality and single molecule control; • Reaching single molecule capturing and tweezing functionality in solid-state nanopore in a way that has not been possible before. This will pave the way to fascinating new discoveries into the fundamental structures of biomolecules and the interaction forces among them.

Data: CORDIS, © European Union

Project objective

In the quest to develop platforms to decipher the information in biomolecules there is an increasingly demand for techniques that are capable of identifying specific biomolecules at the smallest possible concentration, controlling their capturing and movement at the nanoscale. Nanopore sequencing is a key technology to drive this progress, and solid-state nanopores can be a major technological player. In the field of solid-state nanopores, many challenges remain in particular toward i) design and fabricate nanopore with size comparable to biological pores, ii) dynamic control of single molecule translocation, and iii) multiplexed read-out. Progress toward integrated platforms where both solid-state and biological nanostructures are implemented has been brought by the development of functional nanomaterials and DNA nanotechnology, able to address the importance of nanoscale precision in nanopore platforms with the potential to surpass the performance of biological nanopores. Yet, the integration of biological and synthetic nanomaterials is technically challenging, and their use to fully control and measure single molecule is far from real-world applications. DYNAMO is designed as an innovative research and training network, where we will recruit 10 Researchers to work toward the ambitious goal of developing the next-generation single molecule technologies exploiting hybrid DNA and metallic nanostructures. The network brings together a unique team of 8 world-leading academics and 1 high tech innovative company at the forefront of optical spectroscopy, DNA nanostructures, nanopore technology developments, single molecule detection and control, and biotech real-world applications. DYNAMO will establish an intersectoral training and research programme at the physics/chemistry/biotech interface with partners from 6 EU countries, aimed at creating the next generation of skilled well-connected scientists that will pioneer the ‘single molecule science of tomorrow’.

Original text from CORDIS.

Participants

  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA · GenovaCoordinatorItaly
  • ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN NANOCIENCIAS CIC NANOGUNE · San SebastianSpain
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisFrance
  • ELEMENTS SRL · CesenaItaly
  • HUMBOLDT-UNIVERSITAET ZU BERLIN · BerlinGermany
  • TECHNISCHE UNIVERSITEIT DELFT · DelftNetherlands
  • THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEUnited Kingdom
  • UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA · LeioaSpain
  • UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA · MilanoItaly
  • UNIVERSITAET LEIPZIG · LeipzigGermany
  • UNIVERSITE D'AIX MARSEILLE · MarseilleFrance
  • UNIVERSITEIT GENT · GentBelgium

Links

Data: CORDIS, © European Union