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HEDoctoral network2023–2027

BiodeCCodiNNg · Decoding novel reaction chemistries in biocatalysis – Training Europe’s next visionaries for a sustainable future

Horizon Europe — Marie Skłodowska-Curie Actions

Duration
2023-01-01 → 2027-12-31
EU contribution
€2,629,994
Participants
20
Scheme
HORIZON-TMA-MSCA-DN

Lines connect the coordinator with its partners.

Results in brief

Decoding novel reaction chemistries in biocatalysis – Training Europe’s next visionaries for a sustainable future

Enzymes are environmentally friendly alternatives to traditional chemical processes - contributing to the goals of the European Green Deal and Europe's transition to a sustainable bio-based industry. The mission of BiodeCCodiNNg is to train 10 Doctoral Candidates (DCs) with an out-of-the-box and entrepreneurial mindset to expand the repertoire of enzymes for industrial biotechnology. A particular focus is on novel reactions that are not accessible with the existing enzymatic toolbox. In order to achieve this, BiodeCCodiNNg will leverage the beyond-state-of-the-art knowledge generated on C-C bond forming enzymes (CCzymes), while filling current gaps and addressing the paucity of knowledge on the largely untapped family of N-N bond forming enzymes (NNzymes). The BIODECCODING Doctoral Network will train and educate Europe's next 10 visionaries for a sustainable future on cutting-edge enzyme technology centered around N-N and C-C bond formation, addressing technology gaps, practical challenges and exploiting synthetic opportunities with huge innovation potential. This PhD program not only provides in-depth training in an interdisciplinary working environment, but also strengthens transferable skills training with strong industry participation. The objectives will be achieved through an interdisciplinary consortium of 19 leading academic and private organizations, providing the ideal environment to foster complementary expertise in drug discovery, enzyme catalysis and process development.

Data: CORDIS, © European Union

Project objective

Enzyme catalysis is an essential technology at the heart of industrial biotechnology, expected to foster the EU economic growth and industry leadership, while effectively addressing social, environmental, and economic needs. It improves the sustainability of chemical processes and gives rise to new reactivities for multi-functionalized product building. Traditional chemical methods for their synthesis are typically realized by costly and environmentally unfriendly processes. Expanding the toolbox of available biocatalysts enabling novel reactions not yet accessible with the existing enzymes is a formidable challenge, but will open exciting new avenues for applications in the chemical and pharmaceutical industries. The BIODECCODINNG consortium will address this challenge by decoding novel reaction chemistries from the largely underexploited family of N-N bond forming enzymes, while addressing challenging reactions performed by C-C bond forming enzymes that are currently not accessible.The main goal of the BIODECCODINNG DN is to train and educate Europe’s next 10 visionaries for a sustainable future on cutting-edge enzyme technology centered around N-N and C-C bond formations, and to tackle technology gaps, practical challenges, as well as to exploit synthetic opportunities with a huge innovation potential. The network is established by world-leading experts from European academic institutions and industrial partners that will together implement the training agenda. This setting provides strong interdisciplinary co-supervision and intersectoral exposure in secondments to the doctoral candidates, and bridges intersectoral and multidisciplinary boundaries across training in leading-edge drug discovery, enzyme catalysis and process development. BIODECCODINNG will therewith prepare the next generation of researchers for the implementation of sustainable enzymatic processes comprising C-C- and N-N bond forming enzymes in the European Biotech sector.

Original text from CORDIS.

Participants

  • RIJKSUNIVERSITEIT GRONINGEN · GroningenCoordinatorNetherlands
  • AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridSpain
  • ASTRAZENECA AB · SodertaeljeSweden
  • BASF SE · Ludwigshafen Am RheinGermany
  • CHIRALVISION BV · DEN HOORNNetherlands
  • CLUSTER INDUSTRIELLE BIOTECHNOLOGIE EV · DUSSELDORFGermany
  • ENZYMICALS AG · GreifswaldGermany
  • F. HOFFMANN-LA ROCHE AG · BaselSwitzerland
  • FORSCHUNGSZENTRUM JULICH GMBH · JULICHGermany
  • GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS · GottingenGermany
  • Innophore GmbH · GrazAustria
  • PROZOMIX LIMITED · HaltwhistleUnited Kingdom
  • PUROLITE LTD · LLANTRISANTUnited Kingdom
  • RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN · AachenGermany
  • RUHR-UNIVERSITAET BOCHUM · BochumGermany
  • SPINCHEM AB · UmeaSweden
  • SVEUCILISTE U ZAGREBU FAKULTET KEMIJSKOG INZENJERSTVA I TEHNOLOGIJE · ZagrebCroatia
  • UNIVERSITAET GRAZ · GrazAustria
  • UNIVERSITAT DE BARCELONA · BarcelonaSpain
  • ZYMVOL BIOMODELING SL · BarcelonaSpain

Links

Data: CORDIS, © European Union