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HEDoctoral network2023–2027

RBP-ReguNet · Deconstructing and Rewiring RNA-RBP regulatory networks

Horizon Europe — Marie Skłodowska-Curie Actions

Duration
2023-03-01 → 2027-02-28
EU contribution
€2,603,801
Participants
15
Scheme
HORIZON-TMA-MSCA-DN

Lines connect the coordinator with its partners.

Results in brief

Deconstructing and Rewiring RNA-RBP regulatory networks

RNA-binding proteins (RBPs) regulate RNA processes, including transcription, splicing, translation, and decay, and disruptions in these networks are linked to various diseases. Recent studies have expanded the RBP repertoire, uncovering unconventional RBPs like metabolic enzymes with RNA-binding roles. RBP-ReguNet aims to explore these findings for druggable targets in diseases like cancer and neurological disorders, providing advanced training for European researchers to develop RBP-based therapies. Key objectives: 1. Identify RBPs in demyelinating diseases and liver pathologies. 2. Identify key RBPs impacting biological processes in pathological models. 3. Characterize novel RBP molecular functions. 4. Identify small molecule inhibitors for RBPs. 5. Provide high-level training for researchers.

Data: CORDIS, © European Union

Project objective

RNA-binding proteins (RBPs) are critical regulators of gene expression programs. They regulate all aspects of RNA life, including transcription, splicing, modification, localization, stability, translation and decay, and consequently, perturbations in these RBP-RNA networks underlie the origin of many diseases. Recent proteomics-based studies have vastly expanded the repertoire of RBPs to the thousands, uncovering unconventional RBPs such as metabolic enzymes ‘moonlighting’ in RNA-binding activity or RNAs “riboregulating” protein function. This represents a much broader layer of biological control that was previously envisaged, which adds an entirely new dimension to RBP-dependent regulation of cellular homeostasis. RBP-ReguNet has been conceived to leverage these new discoveries to identify druggable targets for a range of untreatable diseases, including cancer, neurological disorders, liver diseases and infectious disease. Our ambition in RBP-ReguNet is to create a high-level training program based on basic research but with a strong impact on clinical translation. RBP-ReguNet will provide advanced multidisciplinary scientific training that spans from computational, structural, molecular and cellular biology to medicinal chemistry and pharmacological screening, to the next generation of European researchers in an intersectoral environment to pursue ambitious and high gain research on the development of new therapies based on RBP biology. They will be trained in a range of core and state-of-the-art discipline-specific research skills, complementary transferable skills, and entrepreneurial skills by secondments to non-academic partners, with a common focus to discover actionable targets. This network of excellence will push the boundaries of knowledge in the protein-RNA interactions universe, and at the same time provide the next generation of students with the skills to become future leaders in the field.

Original text from CORDIS.

Participants

  • UNIVERSIDAD DE SANTIAGO DE COMPOSTELA · Santiago De CompostelaCoordinatorSpain
  • CONSIGLIO NAZIONALE DELLE RICERCHE · RomaItaly
  • EUROPEAN MOLECULAR BIOLOGY LABORATORY · HeidelbergGermany
  • FUNDACIO CENTRE DE REGULACIO GENOMICA · BarcelonaSpain
  • Fundacion Kertor · Santiago De CompostelaSpain
  • IMMAGINA BIOTECHNOLOGY SRL · TrentoItaly
  • INSTITUT CURIE · ParisFrance
  • Ribonexus · VillejuifFrance
  • Stichting Sanquin Bloedvoorziening · AmsterdamNetherlands
  • UNIVERSIDAD POMPEU FABRA · BarcelonaSpain
  • UNIVERSITA DEGLI STUDI DI MILANO · MilanoItaly
  • UNIVERSITA DEGLI STUDI DI TRENTO · TrentoItaly
  • UNIVERSITE PARIS-SACLAY · Gif-Sur-YvetteFrance
  • UNIVERSITEIT VAN AMSTERDAM · AmsterdamNetherlands
  • UNIVERSITY OF GLASGOW · GlasgowUnited Kingdom

Links

Data: CORDIS, © European Union