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HEStaff exchange2022–2027

MX-MAP · Towards MXenes’ biomedical applications by high-dimensional immune MAPping

Horizon Europe — Marie Skłodowska-Curie Actions

Duration
2022-11-01 → 2027-04-30
EU contribution
€1,389,200
Participants
16
Scheme
HORIZON-TMA-MSCA-SE

Lines connect the coordinator with its partners.

Results in brief

Towards MXenes’ biomedical applications by high-dimensional immune MAPping

The MX-MAP project is an innovative initiative addressing global health challenges by leveraging the unique properties of two-dimensional (2D) nanomaterials, specifically MXenes, for biomedical applications. Collaborating across leading academic and industrial partners from Europe, North America, and Asia, MX-MAP integrates interdisciplinary expertise to bridge critical gaps in MXene biocompatibility and immune interactions. The project aims to develop a functional pipeline for MXene immune characterization, enabling their safe use in therapies such as cancer photothermal/photodynamic treatments, regenerative medicine, targeted drug delivery, and antibacterial strategies. By advancing material synthesis, functionalization, and characterization, MX-MAP drives research excellence while fostering the next generation of researchers through hands-on training and collaboration. The outcomes—scalable MXene production, immune profiling tools, and novel therapeutic applications—will contribute to Europe’s strategic priorities in healthcare innovation, positioning the EU as a leader in nanotechnology and biomedical research while improving global health outcomes.

Data: CORDIS, © European Union

Project objective

The long-term goal of MX-MAP is to develop a functional pipeline for the immune characterization of new 2D nanomaterials of MXene family, for the qualitative and quantitative assessment of the human immune compatibility and immune activity towards biomedical applications.The immune characterization of the tested materials on the basis of intrinsic physical-chemical and immunological properties, through the combination of the most innovative technologies such as single-cell mass cytometry (CyTOF), will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators, scaffolds for tissue engineering, cancer therapy, and antibacterial agents. MX-MAP will develop key chemistry and immune-based strategies for MXene medical applications. The implication of this project extends beyond the specific nanoscience program greatly advancing the engineering process of 2D materials and their use in biomedicine.The MX-MAP project involves fourteen key players in European and non-European countries, including the United States, Canada, Saudi Arabia, and three partners from Ukraine, coming from academia and SMEs. This program will provide strong support for the development of the careers of young brilliant scientists who want to grow towards an interdisciplinary vision of Science. Chemistry, biology, immunology, engineering, and cancer research are the expertise of MX-MAP. The senior team members are among the most influential scientists, including Prof. Yury Gogotsi (H-index=168) - inventor of MXenes, Prof. Klaus Ley (H-index=147) - one of the most cited immunologists worldwide, and Prof. Husam N Alshareef (H-index=99). The Consortium is perfectly balanced in terms of equal gender presence; the project Coordinator Lucia Gemma Delogu is a female, and 2 out 4 of four WP leaders are female. The project embraces a large view of inclusiveness and diversity, including countries with smaller economies such as Ukraine.

Original text from CORDIS.

Participants

  • UNIVERSITA DEGLI STUDI DI PADOVA · PadovaCoordinatorItaly
  • ANKARA UNIVERSITESI · Tandogan AnkaraTürkiye
  • Augusta University Research Institute, Inc. · AugustaUnited States
  • CAMBRIDGE RAMAN IMAGING SRL · VeronaItaly
  • DREXEL UNIVERSITY · PhiladelphiaUnited States
  • KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY · ThuwalSaudi Arabia
  • Khalifa University of Science and Technology · Abu DhabiUnited Arab Emirates
  • LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY · La Jolla CaUnited States
  • LATVIJAS UNIVERSITATE · RIGALatvia
  • MATERIALS RESEARCH CENTER · KievUkraine
  • SUMY STATE UNIVERSITY · SUMYUkraine
  • THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN · DublinIreland
  • THE UNIVERSITY OF MANITOBA · ManitobaCanada
  • UNIVERSITA DEGLI STUDI DI SASSARI · SassariItaly
  • UNIVERSITAETSKLINIKUM ESSEN · EssenGermany
  • UNIVERZITET U NOVOM SADU · Novi SadSerbia

Links

Data: CORDIS, © European Union