ClaN-Bi · A general bismuth-based platform for the catalytic construction of carbon–nitrogen bonds and beyond.

A general bismuth-based platform for the catalytic construction of carbon–nitrogen bonds and beyond.

The creation of carbon-nitrogen (C-N) and carbon-carbon (C-C) bonds is a cornerstone of modern chemistry, enabling the synthesis of complex molecules used in medicines, agriculture, and materials. Top-selling drugs rely on C-N bonds to achieve their function, yet traditional methods to form these bonds use expensive and toxic metals like palladium, posing environmental and cost challenges. The ClaN-Bi project aimed to transform this landscape by harnessing bismuth, a non-toxic, as a sustainable catalyst for these critical reactions. Recent discoveries have shown that bismuth can mimic transition metals by cycling through different chemical states (Bi(I) to Bi(III) or Bi(III) to Bi(V)) and generate reactive radicals, offering new pathways for chemical synthesis. Within this project, we pursued two key objectives: 1) Develop new bismuth-based chemical processes, focusing on radical-generating steps and transition metal-like reactions to form C-N and C-C bonds; 2) Establish catalytic cycles using low-valent bismuth to create these bonds efficiently, providing a greener and cheaper alternative to conventional methods. By integrating radical and polar mechanisms, often aided by light-driven (photochemical) steps, the project sought to unlock bismuth’s untapped potential in catalysis. Over the course of this action, we have demonstrated bismuth’s potential to catalyze innovative reactions, inspiring new research directions in chemistry. These advancements could lower production costs for medicines and agrochemicals, making them more accessible.

Data: CORDIS, © European Union