MOR-AGE · Bacterial Methionine Oxidation Repair and Aging
Horizon Europe — Marie Skłodowska-Curie Actions
- Duration
- 2023-05-01 → 2025-04-30
- EU contribution
- €211,755
- Participants
- 1
- Scheme
- HORIZON-TMA-MSCA-PF-EF
Lines connect the coordinator with its partners.
Results in brief
Bacterial Methionine Oxidation Repair and Aging
Cells are constantly exposed to oxidative stress, which can damage essential molecules and affect their survival. Among the molecules targeted, proteins are particularly vulnerable. The MOR-AGE project aimed to better understand how bacteria repair oxidative damage in proteins, and how this process influences their capacity to cope with stress and age over time.
Data: CORDIS, © European Union
Project objective
Identifying the causal molecular processes of aging is a long-standing quest in biology. Oxidative stress is a conserved hallmark of senescence among living organisms, but the underlying mechanisms linking oxidative damage and aging have proved difficult to unravel. Multiple reports pinpoint Methionine oxidation as an important antioxidant system influencing the lifespan of cells. Here, I propose to develop an approach including single-particle tracking and microfludic-based single-cell imaging to visualise Methionine oxidation repair in live E. coli bacteria. Such method is currently lacking in the field and its development, although challenging, could deepen our understanding of how system-level failures emerge out of molecular damage.
Original text from CORDIS.
Participants
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisCoordinatorFrance
Links
- View on CORDIS
- DOI: 10.3030/101106503
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e51acabc66&appId=PPGMS
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e522e10e41&appId=PPGMS
Data: CORDIS, © European Union