Expo-IS-omics · The chemical exposome in pregnant women and metabolic dysregulations analysis towards the prioritization of hazardous chemicals
Horizon Europe — Marie Skłodowska-Curie Actions
- Duration
- 2023-12-01 → 2025-11-30
- EU contribution
- €169,327
- Participants
- 1
- Scheme
- HORIZON-TMA-MSCA-PF-EF
Lines connect the coordinator with its partners.
Results in brief
The chemical exposome in pregnant women and metabolic dysregulations analysis towards the prioritization of hazardous chemicals
The exposome refers to the cumulative exposure to environmental chemicals, which can influence both the health of the mother and the developing fetus. The aim of this project is to characterize the chemical exposome in umbilical cord samples from pregnant women in a semi-quantitative manner, by developing and training appropriate tools for this task. By profiling these exposures, we seek to better understand how they impact the metabolic profile of the mother and child. Specifically, we aim to determine how chemical exposures can alter the metabolome, the set of small molecules found in biological samples. By identifying these alterations, the project intends to create predictive models that could eventually help forecast metabolic disruptions caused by exposure to various chemicals. This could be particularly valuable for preventing potential metabolic diseases or disorders that arise from environmental factors during pregnancy. Ultimately, the goal is to enhance early detection and intervention strategies, providing insights into the effects of environmental toxicants on fetal development and maternal health. The project will integrate high-throughput analytical techniques based on high resolution mass spectrometry data and computational tools to offer a detailed picture of the chemical exposures and metabolic shifts occurring during pregnancy, contributing to a broader understanding of the exposome's role in human health.
Data: CORDIS, © European Union
Project objective
Expo-IS-omics is an interdisciplinary and highly innovative project in the field of human exposomics and bioinformatics. The main objective of EXPO-IS-OMICS is to obtain a holistic picture of both the external and internal chemical exposome in a large cohort of pregnant women to study which are the contaminants that can cause metabolic alterations. Once we know which contaminants are having more effects, we will develop new cheminformatics tools, capable to predict the chemicals with potential to dysregulate human metabolism based on in-silico predicted molecular predictors. EXPO-IS-OMICS will analyse samples of blood and urine of >200 pregnant women residents in Greece from the Rhea Cohort. This project will use state-of-the-art instrumentation to provide nontarget data at trace levels from a vast chemical domain, obtaining with the same data information of both contaminants’ presence (external chemical exposome) and specific alterations in the endogenous chemical profile (internal chemical exposome), by means of target, suspect, nontarget and metabolomics strategies. EXPO-IS-OMICS will also be pioneer in developing cheminformatics tools to predict when a certain chemical may represent a problem to human health. For the development of the tool, experimental data from this project will be joined with others cohort’s results in which the applicant is currently involver and the principal investigators have agreed to share (e.g. BISC (https://www.projectebisc.org/) and Insulin (https://www.tecnatox.cat/list-of-projects)) for validation purposes. The expert knowledge of fellow and host group gives the security to reach the ambitious objectives.
Original text from CORDIS.
Participants
- ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON · ATHINACoordinatorGreece
Links
- View on CORDIS
- DOI: 10.3030/101104517
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e50cc6ea9b&appId=PPGMS
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5275e709f&appId=PPGMS
Data: CORDIS, © European Union