PhotoCage · Photocatalysis as Powerful Tool For Polyene Cyclizations in Supramolecular Cages
Horizon Europe — Marie Skłodowska-Curie Actions
- Duration
- 2024-06-01 → 2026-05-31
- EU contribution
- €173,847
- Participants
- 1
- Scheme
- HORIZON-TMA-MSCA-PF-EF
Lines connect the coordinator with its partners.
Results in brief
Photocatalysis as Powerful Tool For Polyene Cyclizations in Supramolecular Cages
PhotoCage is based on the study of the interaction between photocatalysts and fluorinated alcohols. In this context, fluorinated alcohols are very special solvents in organic chemistry due to their extraordinary chemical and physical properties (e. g. strong H-bonding donor ability, low nucleophilicity). The combination of fluorinated alcohols with PET processes makes this strategy unique for developing new transformations. To achieve PhotoCage, 3 main research objectives were studied: (a) Design of the supramolecular cage photocatalyst and study of the interaction between them; (b) Application of the designed supramolecular cage photocatalyst to new organic reactions; (c) Study of the reaction mechanisms. During the development of the project, we discovered that Eosin Y can disproportionate in two species (EH· and EH3·) in the presence of fluorinated solvents promoting alkene oxidation beyond their oxidation potential. As a result, different intra- and inter- alkene's functionalizations could be achieved. Thus, this finding will allow us to explore multiple alkene functionalizations using different classes of nucleophiles.
Data: CORDIS, © European Union
Project objective
Biosynthetic polyene cycllization, where complex structures are obtained, represents an impressive example of Nature's a chemist. Organic chemists are trying to emulate the Nature to develop synthetic methodologies base on these cascades. It has been demonstrated that Photoinduced Electron Transfer (PET) can achieve this polyene cyclizations under milder conditions, as plants do during photosynthesis. In this context, fluorinated alcohols are very special solvents in organic chemistry due to their particular chemical and physical properties (e. g. strong H-bonding donor ability, low nucleophylicity). The combination of fluorinated alcohols with PET processes make this strategy unique for develop new biomimetic polyzene cyclization. To achieve PhotoCage 4 main research objectives should be implemented: (a) Design of the supramolecular cage photocatalyst and study of the interaction between them; (b) Application of the designed supramolecular cage - photocatalyst to polyene cyclizations; (c) Study of the reaction mechanims; (d) Impementation and development of an asymmetric version. The proposal also offers me a unique opportunity to develop transferable skills thanks to the courses proposed by Saarland University and Professor T. Gulder wich will be a valuable asset for continuing my academic career.
Original text from CORDIS.
Participants
- UNIVERSITAT DES SAARLANDES · SaarbruckenCoordinatorGermany
Links
- View on CORDIS
- DOI: 10.3030/101152106
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5156e7c55&appId=PPGMS
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e52154998e&appId=PPGMS
Data: CORDIS, © European Union