TargetRNA · Targeting RNA with small molecules

Lines connect the coordinator with its partners.

Project objective

RNA molecules play key roles in biological processes and diseases. An emerging avenue to develop innovative medicines is therefore to design small molecule drugs that bind to RNA and affect downstream biological functions. However, to advance this field of research, a new generation of scientists is needed that can further develop and ultimately master the challenging process of drug design applied to RNA. Therefore, the TargetRNA network aims to educate and nurture the next generation of scientists with cutting-edge interdisciplinary skills in the discovery and biological characterization of RNA modulators and thus generate fundamental knowledge on what drives affinity and specificity of small molecules binding to RNA. The objective of TargetRNA is to develop compounds with antimicrobial activity through their interaction with RNA targets, and to use these to selectively reshape the human gut microbiome, an area with vast implications for medicine. Training through research activities, spanning from computational and medicinal chemistry over structural and molecular biology to microbiology and in vivo models, will be supplemented by an innovative training programme in specific and transferable skills for interdisciplinary drug discovery strategies to target RNA, including FAIR data principles, open science practices as well as responsible development and sustainable implementation of new innovations. To achieve the ambitious research and training goals, the TargetRNA network unites leading scientists from 13 academic partners (8 beneficiaries, 5 associated) and 4 industry partners (1 beneficiary, 3 associated) based in 9 countries.

Original text from CORDIS.

Participants

• UNIVERSITETET I BERGEN · BergenCoordinatorNorway
• ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA · BolognaItaly
• ASTRAZENECA AB · SodertaeljeSweden
• CrystalsFirst GmbH · MarburgGermany
• DANMARKS TEKNISKE UNIVERSITET · Kongens LyngbyDenmark
• EUROPEAN INFRASTRUCTURE OF OPEN SCREENING PLATFORMS FOR CHEMICAL BIOLOGY EUROPEAN RESEARCH INFRASTUCTURE CONSORTIUM (EU-OPENSCREEN ERIC) · BerlinGermany
• FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA · GenovaItaly
• JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN · Frankfurt Am MainGermany
• LINKOPINGS UNIVERSITET · LinkopingSweden
• MALVERN PANALYTICAL LIMITED · MALVERNUnited Kingdom
• STICHTING RADBOUD UNIVERSITEIT · NijmegenNetherlands
• SWANSEA UNIVERSITY · SwanseaUnited Kingdom
• Saverna Therapeutics AG · Biel-BenkenSwitzerland
• TECHNISCHE HOCHSCHULE MANNHEIM · MannheimGermany
• UNIVERSITAT BASEL · BaselSwitzerland
• UNIVERSITE COTE D'AZUR · NiceFrance
• UPPSALA UNIVERSITET · UppsalaSweden

Links

• View on CORDIS
• DOI: 10.3030/101168667