ComeInCell · Condensates at Membrane Scaffolds – Integrated Systems as Synthetic Cell Compartments

Lines connect the coordinator with its partners.

Project objective

ComeInCell will establish a novel integrated Synthetic Cell platform to provide cost- and resource-efficient, environmentally friendly, widely applicable and quantitative model systems to elucidate key cellular mechanisms of health and disease based on the integration of condensate and membrane models. Understanding membrane-condensate interactions is vital for deciphering their functional roles in cellular processes. Our consortium employs synthetic vesicles as model systems to explore these interactions. These tailor-made mimics of cellular compartments offer a platform for studying membrane dynamics and the impact of compartmentalization on the activity of reaction networks and the assembly of complex machinery. We will design synthetic cells as life-science prototyping tools to decipher the role of membrane-associated condensates in essential cellular processes linked to membrane transport, membrane transformation, metabolic networks, and repair. The network will confront global challenges, providing solutions in drug development, therapeutics, green-related issues, and synthetic biology. Our goal is to equip junior scientists with cross-disciplinary expertise for developing integrated synthetic cellular testbeds encompassing condensates and membranes, revolutionizing prototyping systems. We will train the next generation of biophysicists, biochemists and bioengineers in rigorous quantitative and mechanistic thinking, while establishing strong ties to young and emerging European SMEs in the health sector for efficient dissemination towards new therapies

Original text from CORDIS.

Participants

• MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENCoordinatorGermany
• AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridSpain
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisFrance
• Dewpoint Therapeutics GmbH · DresdenGermany
• ECOLE NORMALE SUPERIEURE DE LYON · LyonFrance
• HEINRICH-HEINE-UNIVERSITAET DUESSELDORF · DusseldorfGermany
• IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonUnited Kingdom
• INM - LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH · SaarbrueckenGermany
• INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA · KlosterneuburgAustria
• IONERA TECHNOLOGIES GMBH · FreiburgGermany
• KATHOLIEKE UNIVERSITEIT LEUVEN · LeuvenBelgium
• KOBENHAVNS UNIVERSITET · KOBENHAVNDenmark
• LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN · PlaneggGermany
• MD USE INNOVATIONS SL · SANTIAGO DE COMPOSTELASpain
• NANION TECHNOLOGIES GMBH · MUNCHENGermany
• RIJKSUNIVERSITEIT GRONINGEN · GroningenNetherlands
• Refeyn GmbH · BerlinGermany
• STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN · UtrechtNetherlands
• STICHTING RADBOUD UNIVERSITEIT · NijmegenNetherlands
• Springer Nature AG & Co. KGaA · BerlinGermany
• TECHNISCHE UNIVERSITEIT DELFT · DelftNetherlands
• TEL AVIV UNIVERSITY · Tel AvivIsrael
• THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEUnited Kingdom
• The Company of Biologists Ltd · CambridgeUnited Kingdom
• UNIVERSIDAD COMPLUTENSE DE MADRID · MadridSpain
• UNIVERSIDAD DE SANTIAGO DE COMPOSTELA · Santiago De CompostelaSpain
• UNIVERSITA DEGLI STUDI DI SIENA · SienaItaly
• UNIVERSITAET POTSDAM · PotsdamGermany
• UNIVERSITAT DES SAARLANDES · SaarbruckenGermany
• UNIVERSITY OF SURREY · GuildfordUnited Kingdom

Links

• View on CORDIS
• DOI: 10.3030/101168939
• https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e516686595&appId=PPGMS