Adaptmet · Deconstructing adaptive evolution of metastasis

Lines connect the coordinator with its partners.

Project objective

Adaptmet aims to develop an advanced training program encompassing the multifaceted aspects of metastasis adaptation mechanisms, intending to equip budding researchers with the necessary skills to emerge as leaders in this field. A robust mentoring and training strategy, coupled with cutting-edge methodologies and a diverse range of complementary soft skills, are crucial to this endeavour. These skills are imparted through local and network-wide events, fostering seamless research progression, and nurturing successful career trajectories. Scientifically, Adaptmet addresses an unmet medical need by harnessing basic science to revolutionize drug development and, ultimately, enhance patient care. Specifically, scientific work packages (WPs) have been designed to approach metastasis from various functional perspectives. In order to metastasize, cancer cells must adeptly coordinate diverse cellular functions (Cell Fate - WP1). Additionally, understanding the intricate interactions between metastatic cells, the host immune system, and tissue stroma is pivotal (Environment – WP2). Crucial aspects such as the kinetics of metastasis and the mechanisms governing latency, particularly, remain inadequately understood (Latency – WP3). Clarifying this complexity, unravelling mechanisms underlying therapy failure, and identifying expansion pathways are central to defining novel therapeutic targets (Expansion – WP4). In essence, Adaptmet stands at the intersection of a rapidly evolving multidisciplinary domain, amalgamating distinct fields that often face challenges in mutual communication. The success of Adaptmet hinges upon robust partnerships, open exchange of ideas, state-of-the-art methodologies and equipment, and the exploitation of synergistic opportunities among network members. This collaboration spans diverse perspectives, bridging gaps between different disciplines, thereby breaking down barriers and fostering interdisciplinary cohesion.

Original text from CORDIS.

Participants

• FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) · BarcelonaCoordinatorSpain
• ACADEMISCH ZIEKENHUIS LEIDEN · LeidenNetherlands
• BOEHRINGER INGELHEIM RCV GMBH & CO KG · WienAustria
• CANCER STATE THERAPEUTICS · CharleroiBelgium
• DANMARKS TEKNISKE UNIVERSITET · Kongens LyngbyDenmark
• FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH · WienAustria
• FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER · BarcelonaSpain
• FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS · BadalonaSpain
• FUNDACIO INSTITUT HOSPITAL DEL MAR D INVESTIGACIONS MEDIQUES · BarcelonaSpain
• GR ESPANOL DE ESTUDIO Y TRATAMIENTODE INTENSIFIC. Y OTRAS ESTRATEG.EXPERIMENT. EN TUMORES SOLIDOS - GRUPO SOLTI · BARCELONASpain
• HELSINGIN YLIOPISTO · HelsinkiFinland
• INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG · LondonUnited Kingdom
• LUNDS UNIVERSITET · LundSweden
• SCIENSEED SL · MADRIDSpain
• STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS · AmsterdamNetherlands
• Saso Kocevar · HeidelbergGermany
• UNIVERSITAT BASEL · BaselSwitzerland
• UNIVERSITAT DE BARCELONA · BarcelonaSpain
• UNIVERSITAT WIEN · WienAustria
• UNIVERSITE DE LAUSANNE · LAUSANNESwitzerland
• UNIVERSITE LIBRE DE BRUXELLES · Bruxelles / BrusselBelgium
• ZS ASSOCIATES AS · KGS LYNGBYDenmark

Links

• View on CORDIS
• DOI: 10.3030/101169223