METAMIC 3 · Metaproteome-based leveraged microbiome management in the context of One Health

Lines connect the coordinator with its partners.

Project objective

One Health is an integrated, unifying approach that aims to sustainably balance and optimize the health of people, animals, and environment ecosystems. All three domains are interconnected by microbiomes. Microbiomes are present universally and are connected by species exchange, impacting human and animal health but also environmental and biotechnological processes. Targeted control of the taxonomic and functional microbiome composition by microbial effectors such as antibiotics, antimicrobial peptides, and phages could be a game changer for these fields. However, the impact of microbial key factors on modulating microbiomes, the mechanisms implicated and the functional consequences, are barely understood. A novel approach which provides unique insights into the dynamics and the roles of microbial effectors is metaproteomics. The metaproteomics approach allows us to quantify the microbial composition and the expressed metabolic functions as well as to detect phages, antimicrobial resistance associated proteins, and non-ribosomal peptides. Leading European scientists of the Metaproteomics Initiative (https://metaproteomics.org/) formed a strategic alliance to set up a powerful and interdisciplinary network called METAMIC to capitalize on the potential of metaproteomics for developing novel strategies for microbiome control, manipulation/engineering, and restoration based on microbial effectors. METAMIC will achieve this by training a new generation of highly skilled microbiome and metaproteomics scientists, spreading their knowledge in research, industry, the medical sector, and public authorities. Developing novel metaproteomics workflows and exemplifying them in various clinical and biotechnological field studies will provides important steps towards better understanding and managing our microbiomes in the future, fitting the key EU missions, including “climate change”, “climate-neutral and smart cities”, “soil deal”, “restore ocean and water”, and “cancer”.

Original text from CORDIS.

Participants

• LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV · DortmundCoordinatorGermany
• AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridSpain
• AGRO INNOVATION INTERNATIONAL · SAINT-MALOFrance
• COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · ParisFrance
• Centre de Ressources et Competences pour la Mucoviscidose de Montpellier-Occitanie · MontpellierFrance
• ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamNetherlands
• FAGOTERAPIA LAB S.R.L. · SAN GIULIANO TERMEItaly
• FORSCHUNGSZENTRUM JULICH GMBH · JULICHGermany
• HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ · LeipzigGermany
• HOCHSCHULE ANHALT · KoethenGermany
• MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENGermany
• MINISTERE DE LA SANTE ET DE LA SECURITE SOCIALE · LuxembourgLuxembourg
• Microviable Therapeutics, S.L. · GijonSpain
• Myria Biosciences AG · BaselSwitzerland
• PHILIPPS UNIVERSITAET MARBURG · MarburgGermany
• PHYLOGENE · BernisFrance
• ROBERT KOCH-INSTITUT · BerlinGermany
• TECHNISCHE UNIVERSITEIT DELFT · DelftNetherlands
• THE UNIVERSITY OF SHEFFIELD · SHEFFIELDUnited Kingdom
• UNIVERSIDAD AUTONOMA DE MADRID · MadridSpain
• UNIVERSITA DEGLI STUDI DI CAGLIARI · CagliariItaly
• UNIVERSITA DEGLI STUDI DI SASSARI · SassariItaly
• UNIVERSITA DI PISA · PisaItaly
• UNIVERSITAET BIELEFELD · BielefeldGermany
• UNIVERSITAET HOHENHEIM · StuttgartGermany
• UNIVERSITAET LEIPZIG · LeipzigGermany
• UNIVERSITAT WIEN · WienAustria
• UNIVERSITE DE LILLE · LilleFrance
• UNIVERSITE DE MONTPELLIER · MontpellierFrance
• UNIVERSITE DU LUXEMBOURG · ESCH-SUR-ALZETTELuxembourg
• UNIVERSITEIT GENT · GentBelgium

Links

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