NEUROMAGIC · Active nanoMaterials for closed-looP minimaLly-Invasive magneTic sensing and stimUlation of DEep brainstructures

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Project objective

NEUROMAGIC is set to pioneer a groundbreaking approach in the realm of bidirectional brain-machine interfaces (BBMIs) by creatingSmart Anisotropic Magnetic Nanomaterials (SAMNs) for wireless, precise, and cell-specific neuromodulation in deep brain regions.This innovative technology circumvents the need for invasive electrode implants, by establishing a minimally-invasive and highlyeffective communication channel with neurons. By exploiting the unique properties of SAMNs, engineered through the doping ofanisotropic magnetite nanoparticles with divalent transition metals, NEUROMAGIC will to significantly enhance vortex magnetization,facilitating the conversion of magnetic fields into mechanical torques that can trigger neuronal excitation via calcium influx, therebyenabling precise monitoring and modulation of neural activity. We will employ advanced polymer and biomoleculefunctionalization techniques to endow SAMNs with dual capabilities: target specific neuronal populations and read out neural activitythrough calcium signaling. This will be achieved by integrating a calcium-specific protein for direct MRI-based detection of neuralactivity and by functionalizing SAMNs with genetic material and antibodies to achieve cell-type specificity. NEUROMAGIC willleverage an Integrated Computational Materials Engineering (ICME) framework, incorporating text-mining, NLP, and predictive modeling, to optimize the magnetic properties of SAMNs, ensuring their effective passage through the blood-brain barrier and proximity to neuronmembranes. A novel controller system based on reinforcement learning will enable real-time, adaptive neuromodulation tailored toindividual physiological responses. This approach promises to revolutionize the field of BBMIs, offering a versatile platform for bothresearch and therapeutic applications, with the potential to transform the treatment landscape for a range of neurological andpsychiatric disorders.

Original text from CORDIS.

Participants

• UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA · RomaCoordinatorItaly
• ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE · San SebastianSpain
• COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · ParisFrance
• CORTICALE SRL · GenovaCity levelItaly
• FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG · ErlangenGermany
• HELYRA SRLS · RomeCity levelItaly
• NEURANICS LIMITED · GLASGOWUnited Kingdom
• NEUROBITE Technologies Ltd. · GlasgowCity levelUnited Kingdom
• NEUROLANE LTD · ORPINGTONUnited Kingdom
• SVEUCILISTE U ZAGREBU FAKULTET ELEKTROTEHNIKE I RACUNARSTVA · ZAGREBCroatia
• UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA · LeioaSpain
• UNIVERSITATSKLINIKUM ERLANGEN · ErlangenGermany
• UNIVERSITE PARIS-SACLAY · Gif-Sur-YvetteFrance
• UNIVERSITY OF GLASGOW · GlasgowUnited Kingdom

Links

• View on CORDIS
• DOI: 10.3030/101312808