MEDIculous REMeDy · Metabolic disease heterogeneity definition, prevention and remission with targeted interventions

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Project objective

Obesity, diabetes and associated complications constitute a rapidly escalating scientific and societal challenge across Europe marked by profound heterogeneity in causes, clinical trajectories and treatment responses. This heterogeneity explains the limited effectiveness of standardized therapies and highlights the need to stratify metabolic disease. To confront this challenge, MEDIculous REMeDy brings together a pan-European, interdisciplinary doctoral network spanning academia, healthcare, industry, public and patient organizations. The network’s first objective is to train critical and entrepreneurial metabolic health researchers through innovative interdisciplinary, translational and intersectoral training focused on tailored career development, transferable skills and leadership. Gender-responsive research design, open science, public and patient engagement underpin this training culture, equipping DCs with essential skills for academic and non-academic careers. These early-career researchers will drive – and be shaped by – our scientific objectives: (1) to map metabolic disease heterogeneity across the full disease spectrum from early metabolic dysfunction and obesity to advanced diabetes with complications, and (2) to dissect this heterogeneity from underlying molecular mechanisms to biomarkers, therapeutic targets and treatment responses. To achieve its scientific objectives, the consortium will integrate metabolic medicine and computational systems biology that draw on multi-country European patient cohorts, advanced human in vitro platforms and complementary in vivo disease models. This novel integrative strategy enables the development of robust patient stratification and personalized therapeutic approaches applicable across European populations, pushing precision medicine forward. By uniting scientific excellence, pioneering training and societal relevance, MEDIculous REMeDy transforms metabolic disease research and precision medicine across Europe.

Original text from CORDIS.

Participants

• HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH · NeuherbergCoordinatorGermany
• AARHUS UNIVERSITET · Aarhus CDenmark
• DEUTSCHES MUSEUM VON MEISTERWERKEN DER NATURWISSENSCHAFT UND TECHNIK · MunchenGermany
• Deutsches Zentrum für Diabetesforschung e.V. · OberschleiheimCountry levelGermany
• Diabetesseura T1D ry · HelsinkiCity levelFinland
• EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES (EASD) E. V. · DUSSELDORFCity levelGermany
• EVOTEC INTERNATIONAL GMBH · HamburgGermany
• Enamine PL Sp. z o.o. · WrocawCity levelPoland
• FECUNDIS LAB S.L. · Sant Cugat Del VallesCity levelSpain
• FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER · BarcelonaSpain
• GENOS GLYCOSCIENCE DOO ZA ISTRAZIVANJE I USLUGE · OsijekCroatia
• HELSINGIN YLIOPISTO · HelsinkiFinland
• IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonUnited Kingdom
• Ignota Labs Limited · CambridgeCity levelUnited Kingdom
• KEMIJSKI INSTITUT · LjubljanaSlovenia
• KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM) · MuenchenGermany
• KOBENHAVNS UNIVERSITET · KOBENHAVNDenmark
• OHMX.BIO · GENTBelgium
• SANPROBI SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA SPOLKA KOMANDYTOWA · SzczecinPoland
• SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET · ZagrebCroatia
• TECHNISCHE UNIVERSITAET MUENCHEN · MuenchenGermany
• THE GOVERNORS OF THE UNIVERSITY OF ALBERTA · EdmontonCanada
• THE UNIVERSITY OF EXETER · ExeterUnited Kingdom
• TURUN YLIOPISTO · TurkuFinland
• UNIVERSIDAD AUTONOMA DE MADRID · MadridSpain
• UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA · LeioaSpain
• UNIVERSITAET LEIPZIG · LeipzigGermany
• UNIVERSITAT DE BARCELONA · BarcelonaSpain
• UNIVERSITATEA DE VEST DIN TIMISOARA · TIMISOARARomania
• UNIVERZA V LJUBLJANI · LjubljanaSlovenia
• WARSZAWSKI UNIWERSYTET MEDYCZNY · WarszawaPoland

Links

• View on CORDIS
• DOI: 10.3030/101311734