New electrochemical methods using sacrificial anodes for the synthesis of organic compounds

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Project objective

The main target of my work is the reductive electrochemical coupling of polychlorinated methanes and related compounds with alkylhalides and other electrophiles in the presence of a sacrificial anode (Mg, Al, Zn) and, if necessary, in the presence of a mediator or transition metal complexes as catalysts. Depending on the nature of the chlorinated compounds the research can be divided into three parts: Electrolysis of: a) gem-Dichloroalkanes b) Bromotrifluoromethane, Bromochlorodifluoromethane, Dibromodifluoromethane c) Trifluoromethyltoluene, Chlorodifluoromethyltoluene These compounds will be coupled with electrophiles like aldehydes, ketones, carbon dioxide, alkylhalides, DMF and alkanenitriles. The reactions are planned to be carried out in aprotic solvents in an undivided cell. These reactions can replace organometallic procedures and have several advantages, especially concerning industrial synthesis. Even organic halides which are not easily converted to the corresponding organometallic species (e.g. trifluoromethyltoluene) can be readilx carboxylated by electrolysis using a sacrificial anode. Especially the fluorinated compounds are usefill intermediates in the synthesis of pharmaceuticals and pesticides.

Original text from CORDIS.

Participants

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISCoordinatorFrance
• Not availableCity levelGermany

Links

• View on CORDIS