The role of endoglin in the cellular responses to tgf-beta
FP4 — Training and Mobility of Researchers
- Duration
- 1996-02-01 → 1997-01-31
- EU contribution
- —
- Participants
- 2
- Scheme
- RGI
Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.
Project objective
Endoglin is a homodimeric membrane glycoprotein, highly expressed in endothelial cells and macrophages, and with capacity to bind transforming growth factor-Beta (TGF-Beta). Endoglin is a component of the membrane TGF-Beta receptor system, although its specific role in the TGF-Beta induced cellular responses is not known. To study the functional role, we will analyze the TGF-Beta responses of stable transfectants in human U-937 cells expressing two different endoglin isoforms (L-endoglin and S-endoglin) with distinct cytoplasmic tails. U-937 cells are responsive to TGF-Beta, as previously studied in our laboratory, and we will analyze the cellular proliferation, migration, aggregation, fibro- nectin synthesis, upregulation of membrane adhesion molecules, levels of c-myc, c-fos and c-jun mRNA, as well as the TGF-Beta binding capacity of the different membrane receptors.
Original text from CORDIS.
Participants
Links
Data: CORDIS, © European Union