Isolation and characterization of genes specifically involved in somatic hypermutation process by rna differential display
FP4 — Training and Mobility of Researchers
- Duration
- 1996-06-01 → 1998-05-31
- EU contribution
- —
- Participants
- 2
- Scheme
- RGI
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Project objective
The somatic hypermutation process is responsible for the evolution of high affinity antibodies. This phenomenon takes place in the germinal centers, specific structures that develop in the B cell follicles of secondary lymphoid tissues during T-dependent immune response. Germinal centres are formed by two compartments: the dark zone containing the centroblasts and the light zone containing the centrocytes. It appears that somatic hypermutation process takes places place in the dark zone but the molecular mechanisms at the basis of this phenomenon are still poorly understood and are subject of intense investigation. The aim of this project is to separate centroblast and centrocytes subpopulations, extract their RNA and by using m-RNA Differential Display technique isolate the genes involved in the somatic hypermutation process.
Original text from CORDIS.
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Data: CORDIS, © European Union