Role of the fyn molecular complex in human t cell activation and t lymphocyte diseases
FP4 — Training and Mobility of Researchers
- Duration
- 1996-07-01 → 1998-06-30
- EU contribution
- —
- Participants
- 2
- Scheme
- RGI
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Project objective
p59fYn represents one of the protein tyrosine kinase expressed in T lymphocytes whose precise function during T cell activation is poorly understood. To gain insight into the mechanisms by which Fyn is involved in T cell signaling, we propose to purify and clone phosphoproteins that interact with the kinase through its SH2 domain. Subsequently, we will investigate whether the Fyn complex undergoes modifications during T cell activation. Additionally, in order to further assess the critical role of Fyn and its associated proteins, we will also analyze the Fyn complex under pathophysiological conditions, e.g. in T lymphocytes isolated from leukemic patients. The realization of this project could contribute to better understanding the role of Fyn in T cell signaling as well as the mechanisms involved in the developement of T cell lymphomas or leukemias.
Original text from CORDIS.
Participants
Links
Data: CORDIS, © European Union