Role of the ci transcription factor in the hedgehog signal transduction pathway

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Project objective

Role of the Ci transcription factor in the hh signal transduction pathway Recently, the secreted hedgehog (hh) molecule has been shown to play an important role in cell-cell communication in Drosophila and in vertebrates. However, the biochemical mechanisms by which hh regulates the activities, transcriptions, or both of secondary signal transducers is poorly understood. A number of gene products including the serine/threonine kinase fused and the transcription factor cubitus interruptus (Ci) have previously been implicated as putative components of the hh signalling pathway. The objective of this proposal is to gain a more detailed understanding of the molecular basis of hh signal transduction in Drosophila. I will investigate the activity of a number of the components of the putative signalling pathway, focussing on the regulation and function of the Ci protein. These studies should in turn provide insights into the molecular basis of signalling by Hh family proteins in vertebrates.

Original text from CORDIS.

Participants

• Imperial Cancer Research Fund · LondonCoordinatorUnited Kingdom
• Not availableCity levelFrance

Links

• View on CORDIS