Neurophysiological investigation of the mechanisms of long term depression in the rat hippocampus

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Project objective

A neurophysiological investigation will be carried out on the mechanisms of the induction of long-term depression (LTD) and depotentiation (DP) of glutamatergic excitatory synaptic transmission in the rat hippocampus. The research will concentrate on investigating the role of Ca in the induction of LTD/DP, including the role of the influx of Ca via NMDA receptors and voltage-gated Ca stores in releasing Ca or acting as a sink for Ca during the induction of LTD/DP. The stores that will be mainly investigated are those of the endoplasmic reticulum, and in particular, those which are ryanodine-sensitive and inositol 1,4,5-triphosphate-sensitive. The role of each store will be investigated by measuring the induction of LTD/DP in the presence of selective agents which bind to ryanodine or IP3 receptors and either induce or block release of Ca from the stores.

Original text from CORDIS.

Participants

• The Provost Fellows and Scholars of the Holy and Undivided Trinity of Queen Elizabeth near Dublin hereinafter TCD · DublinCoordinatorIreland
• Not availableCity levelItaly

Links

• View on CORDIS