Methods for structure determination by multi-dimensional solid state nuclearmagnetic resonance spectroscopy

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Project objective

The principle problem involved in the determination of structural information by NMR spectroscopy is that of overcoming the extreme complexity of the spectra obtained from abundant spins. I propose to develop multi-dimensional solid state NMR techniques to simplify dramatically the spectrum. The techniques are based on proton detected dipolar local fields. Such techniques have recently been shown to be powerful structural probes in oriented systems, but are much more limited in their application to powdered samples. I propose to introduce improved pulse sequences which will extend the use of these techniques to the measurement internuclear distances in powders. I propose to do this using ideas adapted from a series of recent demonstrations which show that under certain circumstances the NMR behavior of a powder can be made to mimic that of a single crystal. The proposed formalisms and techniques should also have implications for improving the sensitivity and resolution of solid state NMR through their application in other areas such as cross polarization and heteronuclear decoupling. The ideas presented represent a significant step towards the determination of molecular structures in solids by NMR.

Original text from CORDIS.

Participants

• ECOLE NORMALE SUPERIEURE DE LYON · LYONCoordinatorFrance
• Not availableCity levelUnited Kingdom

Links

• View on CORDIS