The synthesis of taxol and analogies via cation-mediated cascade cyclisation
FP4 — Training and Mobility of Researchers
- Duration
- 1997-02-12 → 1998-02-11
- EU contribution
- —
- Participants
- 2
- Scheme
- RGI
Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.
Project objective
The Taxol family of molecules has commanded the attention of the most important synthetic organic chemists due to their unusual tetracyclic structure and, more importantly, to their potent anti-cancer properties. In this project it is intented to develop a new synthetic strategy towards this family of compounds, in which two major fragments are coupled at a late stage in the sequence, and Band C-rings are cyclised in a single step via cation-mediated cascade cyclisation. The cyclohexenyl A-ring acts as a spacer group between the oxetane D-ring acetal and the nucleophilic propargylic silane terminator. The termodynamic driving force for the sequential C-C bond formation will be as a result of formation of increasingly stabilised carbocationic species down the cascade. The novelty of this strategy lies in the cyclisation of a precursor containing intact A and D rings to form B and C rings.
Original text from CORDIS.
Participants
- IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · LONDONCoordinatorUnited Kingdom
- Not availableCity levelSpain
Links
Data: CORDIS, © European Union