The ap-1 transcription factor: function and regulation of ap-1 family members in cell proliferation and differentiation

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Project objective

The proposal concerns a family of transcription factors known as AP-1 that has a crucial role in many important biological processes including cell under this network program. The laboratories involved have a long growth and differentiation, tumour formation and apoptosis. It is composed tradition in exchanging European scientists and in training postdoctoral fellows from different European countries including less favoured ones. All of dimmers between members of the jun and fos families as well as certain members of the ATF2 family. The jun family contains 3 members: cjun, junB the laboratories are situated in well established and internationally and junD; the fos family has 4 members: cfos, fosB, fra1 and fra2; while recognised centres that participate in basic research in many different areas of biology, thus providing a stimulating and scientifically broad the relevant members of the ATF family are ATF2 and ATFa.The aim of the present research network is to understand the role that each individual training environment. The collaborations envisioned as a result of this complex plays in different AP-1 mediated processes and to this end a network will ensure that the trainees will have access to considerable genetic approach will be undertaken aimed at the generation of mutant mice resources and expertise and cell lines that are deficient in, or express an altered form of, each family member. In this way the consequence of altering specific complexes can be ascertained. The participating laboratories have worked in the AP-1field for a number of years and have the combined expertise to follow such a genetic approach. Their collaboration will ensure the exchange of materials and experimental procedures and a cooperative effort in understanding a key factor in the cross-road of many biological processes.

Original text from CORDIS.

Participants

• Imperial Cancer Research Fund · LondonCoordinatorUnited Kingdom
• Christie Hospital NHS Trust · ManchesterUnited Kingdom
• FORSCHUNGSZENTRUM KARLSRUHE GMBH - TECHNIK UND UMWELT · KARLSRUHEGermany
• INSTITUT PASTEUR · PARISFrance
• NATIONAL HELLENIC RESEARCH FOUNDATION · ATHENSCity levelGreece
• RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY · WIENAustria
• Rijksuniversiteit Leiden · LeidenNetherlands
• Stiftung Deutsches Krebsforschungszentrum · HeidelbergGermany

Links

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