Mammalian mrna poly(a) tails, formation removal and function
FP4 — Training and Mobility of Researchers
- Duration
- 1997-01-01 → 2000-12-31
- EU contribution
- —
- Participants
- 8
- Scheme
- NET
Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.
Project objective
We propose to establish a network of collaborating research teams having the mRNA poly (A) tail as a common scientific denominator. All mamalian mRNAs have at 3' ends a 200 residues long poly (A) tail. The poly (A) tail is added post-transcriptionally (nuclear polyadenylation) and this reaction is used by all type of cells to regulate gene expression. In some cells the lengh of the poly (A) tail is metabolised, either by removal or by readdition. Modulating the length of the poly (A) tail regulates translational capacity of an mRNA. Research within this network will increase knowledge in: 1) biochemical details of nuclear polyadenylation. 2) regulation of gene expression through poly (A) site selection 3) functional importance of poly (A) tail metabolism. We propose to establish an advanced school" for training of young post-doctoral fellows. After completion of the three year programme participating fellows should be able to establish independent research programs in their home countries. The young scientists will receive training in: 1) theoretical, experimental and methodological scientific approaches. 2) organisation and execution of advanced practical and theoretical courses/workshops. 3) interaction and communication with other scientists."
Original text from CORDIS.
Participants
- UPPSALA UNIVERSITY · UPPSALACoordinatorSweden
- Centre Médical Universitaire · GenèveSwitzerland
- JUSTUS-LIEBIG-UNIVERSITY OF GIESSEN · GIESSENGermany
- Martin-Luther-Universität Halle-Wittenberg · HalleGermany
- Regional Anticancer-Oncology Hospitalof Athens Saint Saves"" · AthensCity levelGreece
- THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OXFORDUnited Kingdom
- UNIVERSITY OF GLASGOW · GLASGOWUnited Kingdom
- Universität Basel · BASELSwitzerland
Links
Data: CORDIS, © European Union