Synthetic methodology for the development of a new type of antiallergic drug based on the phomactins

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Project objective

Research objectives and content The phomactins" are a new family of intriguing diterpenoid compounds which incorporates several | quaternary centers embedded in an unsual furanochroman and 12/14-membered macrocyclic containing | structure that have recently been isolated. They represent a new and exciting group of novel platelet activating factor (PAF) antagonists and are therefore attractive targets for developing a new type of antiallergic and anti-inflamatory drug. We propose: (i) To develop synthetic methodology for elaborating the key structural features in the phomactins; (ii) To effect total syntheses of members of the phomactins, (iii) To construct a model for the biological activity of the phomactins, and make a contribution towards developing a new type of antiallergic/ anti-inflamatory drug The key strategy to the unified synthetic approach towards several phomactins will be based on (i) elaboration of an activated cyclohexene ring precursor appropriately functionalised for (ii) an endo-macrocyclisation in order to access the key bicyclic intermediate. Training content (objective, benefit and expected impact) The postgraduate training allows to me learning of techniques and topics of organic chemistry which could not be achieved at home institution in Spain. Subsequently I could apply to return to home Institution or spanish industry. Links with industry / industrial relevance (22) Phomactins are a new group of target molecules of economic interest for companies in pharmaceutical chemistry due to their antiallergic and antiinflammatory properties"

Original text from CORDIS.

Participants

• UNIVERSITY OF NOTTINGHAM · NOTTINGHAMCoordinatorUnited Kingdom
• Not availableCity levelSpain

Links

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