Characterisation of stat5 serine kinases in t lymphocytes

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Project objective

Research objectives and content The phosphorylation of STAT5 (signal transducers and activators of transcription) activates gene transcription leading to the growth and acquisition of effector functions of -lymphocytes. This phosphorylation has been described as occurring on tyrosine residues but, very recently, D Cantrell's group has shown that a serine phosphorylation was also involved in STAT5 activation. Interestingly, the serine phosphorylation seems to be required for transcription activation by STAT5 following IL2 stimulation. Additional experiments have shown that none of the known pathways that could lead to he serine phosphorylation of STAT5 (MAP-kinase and phosphatidylinositol 3kinase) were involved in that newly described form of STAT5. Therefore, the IL2-activated serine phosphorylation results from a previously uncharacterised serine kinase. The aim of this project is to identify this protein, describe the pathway leading to its activation, and work out its involvement in T-lymphocyte response to IL2. Training content (objective, benefit and expected impact) The training objective is to deepen my knowledge of T-lymphocyte activation by studying the intracellular signalling following their stimulation. Its benefits will be 1) to get expertise in analysing signal transduction, which is a key step to every immunological process and 2) to interact with leading researchers in immunology and biochemistry. The knowledge and the scientific contacts gained will be applicable in most areas of lymphocyte biology and beneficial to any European group I may join after this post-doctorate.

Original text from CORDIS.

Participants

• Imperial Cancer Research Fund (ICRF) · LondonCoordinatorUnited Kingdom
• Not availableCity levelFrance

Links

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