Study of the 'cross-talk' between two cytokine receptors - ifn - a and il-12 receptors - sharing the protein tyrosine kinase tyk2
FP4 — Training and Mobility of Researchers
- Duration
- 1998-02-01 → 2000-01-31
- EU contribution
- —
- Participants
- 2
- Scheme
- RGI
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Project objective
Research objectives and content Tyk2 belongs to the JAK family of intracellular tyrosine kinase implicated in signaling through cytokine receptors. Tyk2 is activated by IFN-alpha and IL-12 binding to their respective receptors. Tyk2 contributes to IE7N-alpha signaling not only as an active tyrosine kinase, but also by sustaining the steady-state of IFNAR1, one of the two IFN-alpha/beta receptor components. The major goal of my research proposal is to compare the role(s) of Tyk2 in the two receptor complexes and test a model of cross-talk between them. My work will be organized as such: 1. investigate in more depth the observed << dependence >> of IFNAR1 from Tyk2 2. verify if the level of Tyk2 has a comparable role in sustaining the level of the beta1 component of the IL-12 receptor 3. test if the level of IFNAR1 and the cellular response to IFN-alpha can be modified by co-expression within the same cell of another Tyk2-interacting receptor. Training content (objective, benefit and expected impact) The investigation of molecular mechanisms of the regulation of the response to two major cytokines involved in natural and acquired immunity may provide with a paradigm for other cytokine signaling pathways and may help towards understanding the mechanisms of abnormal regulation occurring in cancer and autoimmune diseases. Joining the group of DR.S.Pellegrini will give me the possibility to acquire a stronger theoretical and technical expertise in the field of signaling, in biochemistry and immunology, considering the facilities available in her laboratory and in the Institut Pasteur. Therefore I will be able to apply this knowledge once back to my country of origin, Italy. Links with industry / industrial relevance (22)
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