Asymmetric synthesis of alpha-amino acids

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Project objective

Research objectives and content The main aim of this project is the study of a-amino acid synthesis using new N-dialkylated diketopiperazine based auxiliaries. In order to investigate the regio- and diastereoselective properties of these auxiliaries we shall initiate a programme of research into six areas: 1) An investigation into the general applicability of a novel deprotonation/reprotonation strategy for the preparation of a wide range of a-amino acids. 2) Determination of what protecting groups can be employed for protection on the amidic nitrogens. 3) Development of a new methodology for the preparation of either enantiomer stereospecifically isotopically labelled a-amino acids. 4) Preparation of a wide range of homochiral a,a-bis-alkylated a-amino acids. 5) We wish to implement investigations into a duplication of chirality protocol in order to replicate a-amino acids. 6) Exploration of the possibility of asymmetric synthesis of A,B substituted amino acids by a novel Michael addition approach. Training conent (objective, benefit and expected impact) I think that I shall be able to acquire new knowledges about other methods of asymmetric synthesis of a wide range of homochiral a-amino acids based on stoichometric chiral auxiliaries which are applicable to large scale synthesis.

Original text from CORDIS.

Participants

• THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OXFORDCoordinatorUnited Kingdom
• Not availableCity levelSpain

Links

• View on CORDIS