Modeling dna statistical and dynamical properties

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Project objective

Research objectives and content The available amount of sequences J DNA allows to detect statistical properties that can be interpreted as constraints due to gene functioning anti regulation. Different models for pr`-.u-iotic and eukariotie DNA have been proposed. In parlicular, our attempts to understancd DNA heyontl[?] the nucleotide correlation along the chain made it possible for us to establish a connection between nucleotide statistics and the geomeirieal l'olcding ot' the DNA molecule in eukariotic cells. Time-series analyses will he either inverted or optimised and used, together with those in literature, to extract such information. Together with the biological information available in literature (and also from a close cooperation with with professional biologists), this will allow us to refine our statistics with cukariolie and prokariotie DNA sequences and, compare them with complete genomes available. Exeitation transport properties ol DNA will be studied, together with the influence of nucleotide statistics and correlations on the classical or quantum models Training content Engineering a group with a great experience and moocis, (-)uanmu' i-.-isp`'it in correlated media, anti solutions will enhance the applicant's expertise in these fields, crucial for the project objectives Links with industry / industrial relevance (22) Providing instruments to control better the integration of alien subtences with [?]hullcrCd genotypes, modified through recombinant DNA techniques.

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Participants

• UNIVERSITY OF CRETE · POROS IRAKLEIOU KRITISCoordinatorGreece

Links

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