EC COUPLING IN STRIA · Excitation-contraction coupling and calcium signalling in health and disease
FP5 — Improving Human Research Potential
- Duration
- 2002-10-01 → 2006-09-30
- EU contribution
- €1,500,000
- Participants
- 8
- Scheme
- NET
Lines connect the coordinator with its partners.
Project objective
In skeletal and heart muscle, the signal transduction between the cell surface membrane and the contractile apparatus, called excitation-contraction coupling (ECC), is a model for calcium flux and homeostasis of unique importance. No other organs respond so dramatically to their use or inactivity by hypertrophy or atrophy. Our aim is to study the regulation and molecular basis of ECC in health and disease in man and in animal and cell models.Our goals are:a) to identify novel ECC proteins and characterize their interaction at the molecular level;b) to study localization and targeting of the proteins to their respective compartments, and their interaction using cellular and animal and disease models;c ) to functionally analyze ECC and calcium signaling with high-resolution imaging and electrophysiological techniques;d) to study the genetics and pathophysiology of disease arising from EEC defects. Our proposal integrates a large number of state-of -the-art technologies in the fields of protein biochemistry, molecular genetics, cell biology and physiology.
Original text from CORDIS.
Participants
- UNIVERSITY OF ULM · ULMCoordinatorGermany
- LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK · INNSBRUCKAustria
- National University of Ireland - Maynooth · MAYNOOTHIreland
- UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK · CORKIreland
- UNIVERSITY OF BERNE · BERNSwitzerland
- UNIVERSITY OF DEBRECEN · DEBRECENHungary
- UNIVERSITÀ DEGLI STUDI DI FERRARA · FERRARAItaly
- UNIVERSITÀ DEGLI STUDI DI SIENA · SIENAItaly
Links
Data: CORDIS, © European Union