GENOME STABILITY & C · Linkage between genome stability and checkpoint control

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Project objective

The preservation of genome stability is an essential process in every living organism. DNA can be damaged by a variety of agents and in a number of ways, often with deleterious consequences to cell survival. To prevent such consequences, DNA damage triggers a multitude of responses in eukaryotic cells, including DNA damage signaling and repair, and delay of cell cycle progression until repair is complete. This latter response is referred to as the DNA damage checkpoint". If this checkpoint fails for any reason, genome instability can result. In higher eukaryotes, this can lead to cancer, accelerated ageing and/or certain neurodegenerative disease states. In this application, a set of complementary genetic and biochemical approaches are proposed for the study of the linkage between genome stability maintenance and checkpoint control. The nine laboratories in the proposed network will use biological systems that will allow the efficient integration of these complementary approaches. The main objectives to be addressed are briefly summarized as follows: - To understand the molecular function of DNA helicases involved in the preservation of genomic stability in yeast and humans. These helicases include S. cerevisiae Sgs 1 p, Srs2p, Dna2p, Mph1p, and the human XPB, XPD, BLM and WRN proteins - To establish how the activity of DNA repair and recombination proteins is controlled by checkpoint proteins The achievement of these objectives will allow the network to define the functions and interactions of the different components of the DNA replication, repair and recombination machineries and to understand the regulatory circuits connecting these processes with checkpoint control. This information is a prerequisite to obtaining a complete insight into cellular growth control and how these controls are modified during tumorigenesis and other disease states. "

Original text from CORDIS.

Participants

• University of Cambridge · CambridgeCoordinatorUnited Kingdom
• CANCER RESEARCH UK · LONDONUnited Kingdom
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISFrance
• ERASMUS UNIVERSITEIT ROTTERDAM · ROTTERDAMNetherlands
• GEORG-AUGUST-UNIVERSITY GOETTINGEN · GOETTINGENGermany
• HOSPTIAL UNIVERSITARIO DE CANARIAS (HUC) · LA CUESTA DE ARGUIJONCountry levelSpain
• IFOM FONDAZIONE FIRC DI ONCOLOGIA MOLECULARE · MILANOItaly
• UNIVERSITY OF AARHUS · AARHUS CDenmark
• UNIVERSITY OF ZURICH · ZURICHSwitzerland

Links

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