EURO-RA · Functional Genomic Approaches Targeting Arthritis
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2004-10-01 → 2008-09-30
- EU contribution
- €3,580,223
- Participants
- 11
- Scheme
- RTN
Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.
Results in brief
Final Activity Report Summary - EURO-RA (Functional Genomic Approaches Targeting Arthritis)
The Marie Curie research training network, EURO-RA, brought together leading groups in the field of rheumatoid arthritis research in Europe. Rheumatoid arthritis is a systemic, inflammatory, progressive, chronic and destructive disease affecting primarily peripheral joints, which is associated with pain, disfigurement and various systemic manifestations. It is the most common chronic inflammatory autoimmune disease affecting Europeans. The primary goal of the network was to offer to young researchers the opportunity to participate in a state of the art multidisciplinary training in functional genomics' approaches studying arthritis. This goal was achieved and the network trained 32 fellows during four years. On the other hand, the main scientific goal was to capitalise on the modern post-genome methodologies, such as genome wide expression profiling, proteome analysis, bioinformatics, comparative genomics and mutagenesis, to study rheumatoid arthritis. This combined effort of 12 research groups from nine European countries aimed to identify susceptibility genes that determined the onset, progression and chronicity of autoimmune arthritis. This in turn would provide an excellent opportunity to improve our knowledge on the in vivo disease mechanism and, hence, to develop more rational forms of therapy. The network made considerable progress in that direction. Network scientists published articles in leading scientific journals on those topics and filed patents on experimental therapies for rheumatoid arthritis.
Data: CORDIS, © European Union
Project objective
The Research Training Network, EURO-RA, brings together leading groups in the field of Arthritis research in Europe. The Network primary aim is to offer training on functional genomics methodologies to early stage and experienced researchers. The Network additional aim is fostering the transfer of knowledge between the participating European laboratories. The network will achieve these aims through collaborative research projects and transfer of knowledge tools such as workshops, courses, meetings and secondements. The main scientific goal is to capitalize on the modern postgenome methodologies such as genome-wide expression profiling, proteome analysis, comparative genomics , and genome-wide mutagenesis and linkage analysis to study Rheumatoid Arthritis. Rheumatoid Arthritis is the most common chronic inflammatory autoimmune disease affecting the European population.It is a systemic, inflammatory, progressive, chronic destructive disease affecting primarily peripheral joints, that is associated with pain, disfigurement, and various extraarticular manifestations. This combined effort of 12 research groups from 9 European countries aims to identify genes that determine the onset, progression and chronicity of autoimmune arthritis. This in turn will provide an excellent opportunity to improve our knowledge on in vivo disease mechanism and, hence, to develop more rational forms of therapy. The Network primary aim is to offer training on functional genomics methodologies as applied to autoimmune research to early stage researchers and to and foster transfer of knowledge between the participating European institutes.
Original text from CORDIS.
Participants
- UNIVERSITY OF ROSTOCK · ROSTOCKCoordinatorCity levelGermany
- AREXIS AKTIEBOLAG · GÖTEBORGCity levelSweden
- BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING"" · VARKIZA, VARICountry levelGreece
- BIOXELL S.P.A. · MILANOCity levelItaly
- DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN · BERLINGermany
- IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · LONDONUnited Kingdom
- INSTITUTE OF MOLECULAR BIOTECHNOLOGY OF THE AUSTRIAN ACADEMY OF SCIENCE · VIENNACity levelAustria
- INSTITUTE OF RHEUMATOLOGY · WARSAWCity levelPoland
- LUNDS UNIVERSITET · LUNDSweden
- UNIVERSITY OF ZURICH · ZURICHSwitzerland
- VRIJE UNIVERSITEIT MEDICAL CENTER · AMSTERDAMNetherlands
Links
Data: CORDIS, © European Union