BIOINORGANIC NMR · NMR in Inorganic Structural Biology
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2004-04-01 → 2008-03-31
- EU contribution
- €979,450
- Participants
- 1
- Scheme
- EIF
Lines connect the coordinator with its partners.
Results in brief
Final Activity Report Summary - BIOINORGANIC NMR (NMR in inorganic structural biology)
Fellowships were provided to 20 young researchers and PhD students for a total of 216 person-months, as foreseen in the contract: 7 fellows received grants for at least one year and 13 fellows received grants for less than one year. Among the latter, 2 fellows received grants for 10 and 11 months. Four long term fellowships and two short term fellowships have been provided for allowing six fellows to participate to the Doctoral courses in Structural Biology organised at the Research Infrastructure. Other short term fellowships were provided to fellows demonstrating an enthusiastic approach toward the research activity that we proposed, in order to allow them to acquire successful complementary expertise with respect to their training. The request of training that we received in the whole period has been much larger than what we could offer due to the limited available funds. Young fellows have been trained while developing research in structural biology and providing access to the newest NMR methodologies. They were involved in the most promising forefront research topics developed at the Research Infrastucture. Attention has been focused on framing specific problems in a general context, in an integrated interdisciplinary approach. Research topics spanned from protein expression, structural and dynamics characterisation to the study of protein-protein interactions. The research work performed by the recruited fellows resulted in 23 papers already published in international peer reviewed journals, most of them of high impact factor. Three fellows already successfully discussed their PhD thesis in Structural Biology in Florence, one fellow will discuss it in September 2008 and another fellow in December 2009; most of the other recruited fellows have discussed or are expected to discuss their PhD thesis at their Home Institution.
Data: CORDIS, © European Union
Project objective
This host institution is a Research Infrastructure supported by the European Commission for providing transnational access to biological NMR. The infrastructure is uniquely equipped with a large number of NMR spectrometers ranging from 900MHz down to 0.01MHz, through 800MHz, two 700MHz, 600MHz, 500MHz and 400MHz spectrometers. It has a specialised tradition in the investigation of metalloproteins and in particular of paramagnetic metalloproteins.The aim of this application is that of moving ahead the perspective of Biological Inorganic Chemistry through the training of a new generation of doctorate students, trained at the interface between biology and inorganic chemistry through biocomputing and biospectroscopy. The availability of high technology NMR methods to study at the atomic level the structure and mobility of metalloproteins and their adducts with physiological partners and small synthetic ligands is of crucial importance in the post-genomic era. The use of the genomic databases will be exploited through bioinformatic tools for the selection of proteins for expression and for characterisation in terms of structure, stability, recognition of biological partners, specificity and discovery of new folds and functions.Chemistry oriented fellows will develop aspects related to the role of metal ions in biological systems; biologically oriented fellows will go through an integrated approach from genome to proteins by using high throughput techniques, bioinformatic tools and will be exposed to spectroscopic techniques; biophysics oriented fellows will develop technological and scientific aspects through the use of high and low field NMR and flanking biophysical spectroscopy. The long-term educational aim is to create scientists capable to frame specific problems in a general context, to consider multi-disciplinarity as a primary need and to consider trans-national collaboration as a requirement to develop a coherent generation of European scientists.
Original text from CORDIS.
Participants
- CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE · SESTO FIORENTINOCoordinatorItaly
Links
Data: CORDIS, © European Union