GMNL2003LACTAM · Atropenantioselective lactamizations using an intramolecular Staudinger ligation strategy
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2003-11-01 → 2005-10-31
- EU contribution
- €149,276
- Participants
- 1
- Scheme
- EIF
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Results in brief
Final Activity Report Summary - GMNL2003LACTAM (Atropenantioselective lactamisations using an intramolecular Staudinger ligation strategy)
An intramolecular Staudinger ligation strategy has been disclosed to ring-closed biaryl-type macrolactams. Various ring size of biaryl-macrolactames have been efficiently prepared. In particulary, a 16-membered o,o-dimethyl substituted biaryl containing a medium-sized lactam has been prepared featuring axial chirality as the only asymmetric element. The same product was also prepared using an enantiomerically enriched P-chiral auxiliary but without any detectable asymmetric induction. This researcher has allowed the development of a powerful intramolecular Staudinger ligation strategy to ring-close biaryl-type macrolactams.
Data: CORDIS, © European Union
Project objective
The present proposal concerns the development of atropenantioselective localizations using an intermolecular Standing legation strategy. The study will be undertaken in the Homestead/Van Maureen group at the University of Amsterdam. This group has recently disclosed a novel strategy for the synthesis of medium-sized lactase, and is currently developing the use of the /nframolecular Standing legation in difficult localizations, towards an improved synthesis of several homo- and heterodetically closed cyclopeptides. Future work proposed herein will be dedicated to the particularly challenging stereo selective synthesis of cyclopeptides exhibiting atropisomerism. Striking examples of related bioactive products are RP 66453 (neurotensine receptor antagonist) and the glycol part of vancomycin (glycopeptides antibiotic)
Original text from CORDIS.
Participants
- UNIVERSITEIT VAN AMSTERDAM · AMSTERDAMCoordinatorNetherlands
Links
Data: CORDIS, © European Union