STATPAX · IL-7 dependent commitment of lymphoid progenitors to the B cell pathway
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2005-03-01 → 2007-02-28
- EU contribution
- €157,886
- Participants
- 1
- Scheme
- EIF
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Results in brief
Final Activity Report Summary - STATPAX (IL-7 dependent commitment of lymphoid progenitors to the B cell pathway)
B Lymphocytes produce antibodies which are important for humoral immunity. This project integrated the role of IL-7 signalling into our current understanding of the transcriptional control of B cell development. The experiments provided novel and important insights by determining the molecular consequences of IL-7 signalling for early B cell development. The interleukin7 receptor was composed in part by the common gamma chain receptor as well. A common cause of human x-linked severe combined immunodeficiency was caused by a mutation in this common gamma chain receptor. We thus added to our knowledge on how this signalling axis works.
Data: CORDIS, © European Union
Project objective
During the course of evolution, the immune system has developed to defend us against infections by creating a diverse number of specialized cell types. B-lymphocytes are produced by the differentiation of hematopoietic stem cells (HSC) into gradually more lineage-restricted progenitors. This B cell pathway requires the coordinate action of the early transcription factors PU.1 and Ikaros prior to the activation of the B-cell-specific regulators E2A, EBF and Pax5. In addition, interleukin-7 (IL-7) signalling instructs the initial differentiation of B-lymphocytes from the common lymphoid progenitor. This project will investigate how IL-7 signalling, through activation of the transcription factor STAT5, is integrated into the transcriptional control of early B c ell development.
Original text from CORDIS.
Participants
- RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY (IMP) · VIENNACoordinatorCity levelAustria
Links
Data: CORDIS, © European Union