THIOCARB · Thiocarboxylic Acid Derivatives: New Tools in Organofluorine Chemistry
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2005-01-15 → 2006-01-14
- EU contribution
- €40,000
- Participants
- 1
- Scheme
- ERG
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Results in brief
Final Activity Report Summary - THIOCARB (Thiocarboxylic Acid Derivatives: New Tools in Organofluorine Chemistry)
The basic concept of the project THIOCARB was to explore the combination of the specific properties of sulphur, fluorine and silicon to develop an innovative chemistry towards new fluorinated reagents, building blocks and target compounds. The project addressed the investigation of new cascade (domino) reactions based on dithiocarboxylic acid derivatives. The initial idea was to take profit of the ability of the carbon sulphur double bond to add nucleophilic reagents at sulphur (thiophilic addition) in suitable circumstances and to combine this addition with the elimination of a nucleofugal group. Such a process would lead to a ketene dithioacetal the structure of which depending on both the substrate and the nucleophile. Another important aspect of the project was the application of the above mentionned strategy in the very important field of organofluorine compounds, in order to have access to original processes and original products. The presence of fluorine either on the dithiocarboxylic substrate or on the nucleophilic reagent was considered, with two completely different objectives in term of targeted compounds and also in term of applications.
Data: CORDIS, © European Union
Project objective
Within the tremendous development of organic chemistry, several specialized field have gained their own fame, both from their fundamental interest and their application. The organic chemistry of the heteroelements is symbolic of how can be artificial the c lassification of the sub-disciplines. Almost each heteroelement has its own international symposium, as if any heteroelement should be developed ignoring the others, such over specialization may restrict the creativity of the chemists whose mission is to e xplore any combination between the elements.Owing to the size of fluorine atom (the smallest element after hydrogen) and its electronegativity (the most electronegative element), its introduction into organic molecules induces considerable modification of their physico-chemical and biological properties. As a result, the family of organofluorine compounds play a crucial role in materials, pharmaceutical, agrochemical and more generally bioorganic chemistries. On the other hand, numerous very important organ ic reactions are the result of sulfur and/or silicon-mediated transformation of functional groups.The purpose of this project is to combine specific properties of sulfur and silicon derivatives to create new tools for the development of new reactions/produ cts in the field of organofluorine compounds.The key intermediates and reaction concepts of the project are:- thiocarboxylic acid derivatives- thiophilic nucleophilic attack- the high fluorophilicity of silicon- nucleophilic trifluoromethylation- electroph ilic trifluoromethylation.
Original text from CORDIS.
Participants
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISCoordinatorFrance
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Data: CORDIS, © European Union