MICROFLUIDIC DEVICES · HYBRID MICROFLUIDIC DEVICES FOR COMPLEX CHEMICAL ANALYSIS
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2006-04-15 → 2010-04-14
- EU contribution
- €1,113,617
- Participants
- 1
- Scheme
- EXT
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Results in brief
Final Activity Report Summary - MICROFLUIDIC DEVICES (Hybrid microfluidic devices for complex chemical analysis)
Chemical analysis has developed dramatically over the past decades impacting on large areas of life sciences including biological, biomedical, medical diagnostic needs for an ageing population, environmental monitoring of our fragile ecosystems, pharmaceutical research, monitoring of industrial processes, and other areas. This project explored and characterised new miniaturised analytical methods. Separations, both as a sample preparation and as the main analytical technique employed in the analysis, using a variety of mechanisms (electroseparation, chromatographic partitioning) were employed. Novel modern approaches to using hybrid microfluidic devices for miniaturised analysis were developed. The Team became well known for its pioneering work in utilising the 21st century solid state light sources technology, namely light emitting diodes (LEDs) and laser diodes (LDs), offering unprecedented advantages for miniaturised analysis. Solid state light sources such as LEDs and LDs were utilised for optical detection and for photopolymerisation to create monolithic stationary phases derivatised with necessary special chemistries were employed for techniques utilising a chromatographic stationary phase.
Data: CORDIS, © European Union
Project objective
Chemical analysis has developed dramatically over the past decades but so have the requirements of information-hungry biological, biomedical, and other sciences, medical diagnostic needs for an ageing population, environmental monitoring of our fragile eco systems, pharmaceutical research, and monitoring of industrial processes, and others. Especially in respect to the speed and throughput of the analytical methods, these requirements cannot be met without miniaturisation, following the general principle th at processes proceed faster on a smaller scale.This project µ Fluidic Analysis will investigate and characterise new miniaturised analytical methods by creating complex microfluidic analytical devices. It will use a new flexible approach termed Hybrid Mic rofludic Analytical Device (HMAD), characterised by in-line hyphenation of miniaturised microfluidic chip-based and off-chip functional modules. Microfluidic filtration, microdialysis, micro-solid phase extraction and pre-separation derivatisation of the analytes, used singly and in combination, will be combined in-line with an analytical chip-based device. Separations, both as a sample preparation and as the main analytical technique employed in the analysis, will be using a variety of mechanisms (electr oseparation, chromatographic partitioning). Those techniques utilising a chromatographic stationary phase will be particularly utilising the modern approaches of using photopolymerisation to create monolithic stationary phases derivatised with necessary s pecial chemistries. New approaches to detection will be examined: optical - absorption photometric and fluorimetric, including time-resolved fluorescence, use of light emitting diodes (LEDs) and laser diodes (LDs), combination with pre-detection derivatis ation, and a new electrochemical detection technique termed pulsed potentiometric detection introduced by the Team Leader.The outcomes of µ Fluidic Analysis will include Research, Training and Technology.
Original text from CORDIS.
Participants
- DUBLIN CITY UNIVERSITY · DUBLINCoordinatorIreland
Links
Data: CORDIS, © European Union