GRADIENT COMPOSITES · Novel multicomponent polymer systems with compositional gradient for biomedical application
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2005-09-01 → 2006-08-31
- EU contribution
- €106,445
- Participants
- 1
- Scheme
- IIF
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Results in brief
Final Activity Report Summary - GRADIENT COMPOSITES (Novel multicomponent polymer systems with compositional gradient for biomedical application)
A novel approach to biomaterials has emerged as a consequence of the development of multicom-ponent polymer systems with compositional gradient. The synthesis of unique polymer composites with controlled mechanical properties and required surface chemistry was done. The gradient polymer composites were engineered using biocompatible monomers which improved the biocompatibility of existing polymer systems while retaining certain mechanical and physical properties. The studies were performed on two series of the gradient semi-interpenetrating polymer networks with varied composition at different depths from the surface, which consist of the polyurethane elastomer and biocompatible hydrophilic polymers polyvinylpyrrolidone and poly(hydroxyethyl methacrylate). The thermodynamic miscibility, phase distribution, morphology, dynamic mechanical properties, dielectric properties, bacterial adhesion and cytotoxicity of semi-interpenetrating polymer networks and gradient polymer composites have been investigated. It was shown that biocompatibility of polymer materials can be substantially improved playing on the nanoscale morphology created by hydrophilic polymers in the surface layers of matrix polymer. The altering of nanostructure at the surface of polymer composites allow to reduce the bacterial adhesion. The creation of the gradient semi-IPNs based on polyurethane and poly(hydroxyethyl methacrylate), polyurethane and polyvinylpyrrolidone allow to save the mechanical properties of samples in hydrated state on the tolerable level for using them in bioengineering purpose. Taking into account that the semi-IPNs and gradient composites with poly(hydroxyethyl methacrylate) content above 22 % are not toxic, the results suggest that the composites may have optimised characteristics as advanced biomaterials.
Data: CORDIS, © European Union
Project objective
A novel approach to biomaterials has emerged as a consequence of the development ofmulticomponent polymer systems with compositional gradient. This approach allows the synthesis of uniquepolymer composites with controlled mechanical properties and required surface chemistry. The abilityto engineer gradient polymer composites using biocompatible monomers will make it possible toimprove the biocompatibility of existing polymer systems while retaining certain mechanical andphysical properties.We plan to develo p the method of engineering of the polymer composites with gradient layers ofbiocompatible polymer. The main advantage of this method is the exceptional flexibility in the creationof the materials with required properties. The studies will be done on two s eries of the gradientinterpenetrating polymer networks with varied composition at different depths from the surface, whichconsist of the polyurethane elastomer and biocompatible hydrophilic polymers polyvinylpyrrolidoneand poly(hydroxyethyl methacrylate). We are going to study the characteristics of gradient polymercomposites with respect to their structure, physico-chemical properties and biocompatibility as well asto investigate the thermodynamics and kinetics of synthesis of gradient composites, their mo rphologyand miscibility, relaxation properties.Not only a scientific but also a practical value has this project. Due to unusual complex of physico-mechanical and physico-chemical properties that gradient composites may possess, this approach offersan attr active opportunity for the creation of advanced biomaterials. There is a great interest inbiocompatible polymer materials nowadays because of their application in medicine. In the hostlaboratory the biomaterials have already been investigated in collaborat ion with the industry. It ispossible that the project will find an industrial interest and will be continued.
Original text from CORDIS.
Participants
- UNIVERSITY CLAUDE BERNARD LYON 1 · VILLEURBANNECoordinatorCity levelFrance
Links
Data: CORDIS, © European Union