BRAIN BIOENERGETICS · Brain Bioenergetics
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2005-06-01 → 2009-05-31
- EU contribution
- €700,965
- Participants
- 7
- Scheme
- TOK
Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.
Results in brief
Final Activity Report Summary - BRAIN BIOENERGETICS
The main objective of the project was to reinforce the research potential of centre of molecular medicine at university of Tartu in brain bioenergetics in its most emerging fields. The project involved two components: - First, transfer of theoretical know-how in fields that have been neglected in centre. During the project we hosted two incoming fellows (both for two years) having experience in field of bioinformatics and mitochondrial genomics. - Second, our staff made altogether 13 short time visits (from 1.5 to 7 months) to our training partners for transfer of practical know-how. These short-term visits were directed toward gathering the methodological competence and as well for facilitating scientific cooperation with outstanding research groups aboard. As a measurable outcome of the project we published 15 (from which 14 are joint publications with our training partners) scientific publications in refereed international journals and submitted two patent applications. We would like to highlight four particularly innovative developments: 1. Discovery of the role of the Miro proteins in mitochondrial transport jointly with research groups from university of Ferrara and Thomas Jefferson University that was published proceedings of the National Academy of Sciences. 2. Extensive review about GAD65 in autoimmunity written together with Professor Ake Lermark from University of Lund in advances of immunology. 3. Discoveries related with the role of mitochondrial volume (jointly with Professor Vladimir Veksler from INSERM) and mitochondrial biogenesis in neurons summarised in two papers published in the Journal of Biological Chemistry. 4. European and national patent applications related with the use of transgenic animal model for modelling of pathological anxiety project has thus facilitated considerably our scientific cooperation with outstanding European laboratories as well as improved our research capacity.
Data: CORDIS, © European Union
Project objective
The scientific goal of present project is to find the answers for several specific but important questions of brain bioenergetics, a relatively poorly studied area in the field of brain research that has an enormous impact in neuro-degenerative diseases one of the largest groups of the diseases with great social burden. Brain bioenergetics is one of the fourth main research directions in our Centre and most of our research in this field is (or will be) focussed on few hot spots" that include mitochondrial genomics, mitochondrial biogenesis, mitochondrial traffic and oxidative stress. However, we feel, that additional contribution to the human mobility and transfer of knowledge could significantly increase our capacity and scientific outcome. The present proposal was therefore specifically designed to meet these needs.The main objective of current project is to reinforce the research potential of our Centre in brain bioenergetics in its most emerging fields were our own competence is weak. The project involves two components: First, transfer of theoretical know-how in fields that have been neglected in Centre. This includes a two-year position for professor of bio-informatics whose task will be to establish the interdepartmental core unit of bio-informatics and a two-year position for experienced postdoctoral researcher who will support our efforts in mitochondrial genomics. Second, short term visits of our experienced researchers to foreign labs for transfer of practical know-how.These short-term visits will b e directed toward gathering the methodological competence in brain bioenergetics and as well for facilitating scientific cooperation with outstanding Centres aboard. We are sure that the expected deliverables of these activities -improved capacity building and increased scope of the Centre - will lead to further integration of our Centre, and as well the Estonian medical research in general, into the European Research Area."
Original text from CORDIS.
Participants
- UNIVERSITY OF TARTU · TARTUCoordinatorEstonia
- INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · PARISFrance
- KING'S COLLEGE LONDON · LONDONUnited Kingdom
- LUND UNIVERSITY · LUNDSweden
- MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG · HALLE (SAALE)Germany
- STOCKHOLM UNIVERSITY · STOCKHOLMCity levelSweden
- UNIVERSITÀ DEGLI STUDI DI FERRARA · FERRARAItaly
Links
Data: CORDIS, © European Union