ICR-FTMS · Ion Cyclotron resonance Fourier transform mass Spectrometry
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2005-06-01 → 2009-05-31
- EU contribution
- €126,499
- Participants
- 2
- Scheme
- TOK
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Results in brief
Final Activity Report Summary - ICR-FTMS (Ion cyclotron resonance Fourier transform mass spectrometry)
During the duration of this Marie Curie Action (MCA) project the 14 scientific papers in peer reviewed journals were already published or had been submitted. Furthermore, one book chapter was written, 35 posters were presented at conferences and 13 talks, including plenary lectures, were delivered. All the generated results had a common denominator. The Fourier transform ion cyclotron resonance mass spectrometry was used as a common analytical tool for solving different structural problems. The transfer of knowledge in this field was delivered from the University of Warwick, United Kingdom and the Massey University, New Zealand, to the Institute of Microbiology, Czech Republic.
Data: CORDIS, © European Union
Project objective
The protein expression by itself and the dynamics during disease are at the moment of major biochemical and medical interest. Mass spectrometry is one of the disciplines, which has allowed the study of proteins in that context. The demand for even more sophisticated and more expensive instrumentation such as the Fourier transform Ion cyclotron resonance mass spectrometers (FTICR) has increased due to the ever growing need to study intact proteins and their interactions with other proteins and ligands. Only a handful of such instruments exist in the European union while a larger number exists in the Unites states of America providing the USA with a leading edge in the study of intact proteins by mass spectrometry.An FTICR instrument with the capacity to detect and isotopicaly resolve intact proteins has been recently purchased by the host institute in the Czech republic with funds allocated by the Czech government who immediately recognised the potential and the benefits such analytical capacity will bring. This is the only instrument that has been purchased by any of the new entrants of the European Union and is expected to increase competitiveness of the EU in relation to other major players such as USA and Japan in biochemistry and drug development.The host institute will serve the research and analytical needs of the Czech republic and the neighbouring countries such as Poland, Slovakia and Hungary. Success to the large task undertaken by the Institute of microbiology in the Czech republic on providing regional mass spectrometry expertise can be ensured if technical know-how on the operation of such instrumentation and managerial expertise on operating facilities of that scale is transferred by another institute, which has fulfilled a similar role in another member state. The training offered in FTICR at the University of Warwick (a Marie Curie training site) conforms to the highest standards and is being recognised as a centre of excellence worldwide.
Original text from CORDIS.
Participants
- INSTITUTE OF MICROBIOLOGY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC · PRAGUE 4 KRCCoordinatorCountry levelCzechia
- UNIVERSITY OF WARWICK · COVENTRYUnited Kingdom
Links
Data: CORDIS, © European Union