POLY-MS · Polymer characterisation using electron capture dissociation and collision-induced dissociation multistage mass spectrometry
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2006-04-01 → 2010-03-31
- EU contribution
- €958,819
- Participants
- 4
- Scheme
- EST
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Results in brief
Final Activity Report Summary - POLY-MS (Polymer characterisation using electron capture dissociation and collision-induced dissociation multistage mass spectrometry)
Tandem mass spectrometry is of great importance for structure analysis of polymers. Yet a lot of basic information on fragmentation of polymers in mass spectrometry is missing from the literature. The POLY-MS project focussed on the advancement of the understanding of the behaviour of polymers in multistage mass spectrometry. To this end model polymer systems were synthesised and subjected to multistage mass spectrometry. Moreover, realistic samples from normal polymer research practice were prepared and subjected to analysis. In these cases the added value of application of multistage mass spectrometry, where necessary in combination with advanced separation techniques, was clearly demonstrated. The project also demonstrated the potential for expansion of the capabilities of standard ion trap mass spectrometric instrumentation. An example was the use of the isotope ratios of fragments for structure elucidation purposes. This could be done on standard ion trap instrumentation without a lot of optimisation. Another example, which required optimisation efforts and might for some instruments even require software modifications, was the demonstrated use of fragmentation energy as an indicator of the polymer type. Understanding the size dependent behaviour of fragmentation of polymers as researched in the project was an important step forward for polymer mass spectrometry. The integrated research approach which combined polymer synthesis, general polymer characterisation, separation, multistage mass spectrometry and modelling proved to be a prerequisite for success.
Data: CORDIS, © European Union
Project objective
Millions of tons of a great variety of polymers are synthesised every year to serve a multi-billion Euro market. Responsible entrepreneurship of manufacturers of polymers and surface chemicals focuses the research efforts on environmental risk, biodegradability, sustainability, durability and optimisation of properties to fit the customers' needs. Mass spectrometry plays an important role in the characterisation of the polymers designed. Yet, a knowledge base and experience must be generated to facilitate t he choice of experimental conditions for fast and accurate structural characterisation by multistage mass spectrometry.The POLY-MS project comprises six challenging Marie Curie Early Stage Research Trainings to generate knowledge of mechanisms that play a role in multistage mass spectrometry of different polymer classes. Collision-induced dissociation and electron capture dissociation of polymers will be investigated. Modelling of reaction kinetics and quantum chemical calculations will be carried out to provide a theoretical perspective and interpret the observations. Another task is to devise a methodology for implementation of automated atmospheric pressure ionisation multistage mass spectrometry as high-throughput structure analysis of products from high-throughput experimentation. The project consortium is a strong combination of three academic partners and one industrial partner.The project will allow the six research fellows to develop research skills in mass spectrometry, ion physics and separation techniques in a dynamic and stimulating environment. It will allow the research fellows to develop a variety of complementary skills. Fast and accurate characterisation of research oligomers and polymers accelerates, by improving the understanding of their structure, the development of more durable and environmentally friendly materials. It will thus shorten the design cycle of new materials and thereby improve the competitiveness in the market.
Original text from CORDIS.
Participants
- AKZO NOBEL CHEMICALS BV · ARNHEMCoordinatorNetherlands
- JAN DLUGOSZ UNIVERSITY · CZESTOCHOWACity levelPoland
- KEMIAI KUTATOKOZPONT - MAGYAR TUDOMANYOS AKADEMIA · BUDAPESTCity levelHungary
- STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE - FOM · UTRECHTCity levelNetherlands
Links
Data: CORDIS, © European Union