RECEPTEUR · Cytokine receptor traffic, signalling and human disease
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2006-11-01 → 2010-10-31
- EU contribution
- €2,169,148
- Participants
- 9
- Scheme
- RTN
Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.
Results in brief
Final Activity Report Summary - RECEPTEUR (Cytokine receptor traffic, signalling and human disease)
The Marie Curie Research Training Network RECEPTEUR (November 1, 2006 until 31-10-2010) focused on the relationships between cytokine receptor trafficking, signalling and human disease. The network consisted of 9 partners, including the SME PamGene. Major tasks of the network were to train 9 early stage researchers (ER and ESR) in specific research technologies (network-associated) and more general aspects of research training and career development. The scientific goals of the project were to provide training, acquisition of knowledge and development of technology aimed at dissecting the role of cytokine receptor function in relation to intracellular traffic in the context of chronic immune diseases, disturbed immune responses in cancer, and receptor signalling in the hematopoietic system and their dysfunction in hematological malignancies. Major achievements of this network include the successful training of the ER/ESRs, who were all successful in setting a next step in their careers, and the establishment of a scientific and training network between the partner laboratories that will last beyond the duration of the RECEPTEUR network. Additional highlights within the network included the broad scientific meetings and network meetings, which provided a highly stimulating atmosphere for the exchange of new ideas and technologies. Together, these meetings attracted well over 600 attendants from different European countries as well as from outside Europe.
Data: CORDIS, © European Union
Project objective
Cytokines and their receptors play a crucial role in blood formation, inflammatory responses and immune defences. Defects in cytokine receptors or in the associated janus kinases (JAKs) have been linked to chronic disease, such as severe combined immuno deficiencies, congenital neutropenia, myeloproliferative disorders, leukaemia and autoimmune diseases. Members of this RTN have been involved in the discovery of JAKs, cloning of genes encoding cytokine and cytokine receptors and identification of mutant receptors and JAKs in human diseases.The overall objective of this RTN is to decipher the mechanisms by which JAKs affect the traffic and consequently the signalling outcomes of a number of cytokine receptors relevant to normal hematopoietic and immune functions and associated diseases. Findings revolving around the cytokine receptor-JAK scaffold will be exploited to ultimately modulate receptor levels, spatial configuration, ligand sensitivity and signalling duration towards therapeutic purposes.To this end, we will:(1) Share and combine expertise, knowledge, reagents and technologies to dissect common and differential mechanisms and functional consequences of cytokine receptor traffic in normal and pathophysiological conditions of the hematopoietic and immune systems,(2) Train early stage researchers (ESR) and experienced researchers (ER) in state-of-the art cytokine receptor biology and multifaceted technologies,(3) Exchange ESR and ER among the different laboratories for short-term or longer-term, to promote their scientific and technical skills and to allow them to participate in postgraduate scientific and technology courses,(4) Organize regular meetings with network participants and invited speakers in which ER and ESR can communicate with and present t heir work to an international forum of experts in the field and(5) Train and promote transfer of knowledge at the interface of academia, industry and society.
Original text from CORDIS.
Participants
- ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · ROTTERDAMCoordinatorNetherlands
- CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY · BRUXELLESBelgium
- INSTITUT PASTEUR · PARISFrance
- PAMGENE INTERNATIONAL · S-HERTOGENBOSCHNetherlands
- QUEEN'S UNIVERSITY BELFAST · BELFASTUnited Kingdom
- TAMPEREEN YLIOPISTO · TAMPEREFinland
- UNIVERSITAETSKLINIKUM AACHEN · AACHENGermany
- UNIVERSITE DE LUXEMBOURG · LUXEMBOURGCity levelLuxembourg
- Vlaams Interuniversitair Instituut voor Biotechnologie · GentBelgium
Links
Data: CORDIS, © European Union